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Cefazolin sodium pentahydrate combined with vacuum sealing drainage in the treatment of open fracture complicated with soft tissue injury
- Source :
- Revista da Associação Médica Brasileira, Vol 66, Iss 4, Pp 430-436 (2020), Revista da Associação Médica Brasileira v.66 n.4 2020, Revista da Associação Médica Brasileira, Associação Médica Brasileira (AMB), instacron:AMB
- Publication Year :
- 2020
- Publisher :
- Associação Médica Brasileira, 2020.
-
Abstract
- SUMMARY OBJECTIVE To investigate the clinical efficacy of cefazolin sodium pentahydrate combined with vacuum sealing drainage (VSD) in the treatment of open fracture complicated with soft tissue injury. METHODS Sixty-three patients with open fracture complicated with soft tissue injury were divided into observation (n = 33) and control (n = 30) groups. After surgical reduction, fixation, and repair of the fractures, the control group was treated with VSD for 10 days, and the observation group was treated with cefazolin sodium pentahydrate based on VSD for 10 days. The infection control time was recorded. After treatment, the pain of patients was evaluated. Before and after treatment, the serum levels of C-reactive protein (CRP), interleukin (IL)-6, IL-8, tumor necrosis factor α (TNF-α), cortisol, epinephrine, norepinephrine, and glucose were detected. After 6 months of treatment, the total effective rate of the treatment was evaluated. RESULTS The infection control time and Visual Analogue Scale score after treatment in the observation group were significantly lower than in the control group, respectively (P < 0.05). After the treatment, the serum levels of CRP, IL-6, IL-8, TNF-α, cortisol, epinephrine, norepinephrine, and glucose in each group were significantly lower than before the treatment (P < 0.05), and each index in observation was significantly lower than in the control group (P < 0.05). CONCLUSIONS In the treatment of open fractures complicated with soft tissue injury, cefazolin sodium pentahydrate combined with VSD can effectively reduce inflammation and stress, thus improving the treatment efficacy.
- Subjects :
- Fractures, open
Medicine (General)
medicine.medical_treatment
Cefazolin
Inflammation
Cefazolin Sodium
030207 dermatology & venereal diseases
03 medical and health sciences
0302 clinical medicine
R5-920
Negative-pressure wound therapy
medicine
Soft tissue injuries
Humans
030222 orthopedics
Wound Healing
business.industry
Interleukin
General Medicine
medicine.disease
Anti-Bacterial Agents
Epinephrine
Treatment Outcome
Anesthesia
Soft tissue injury
Drainage
medicine.symptom
business
Wound healing
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 18069282
- Volume :
- 66
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Revista da Associação Médica Brasileira
- Accession number :
- edsair.doi.dedup.....1e46ca72eced310793d989fce8812219