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Additional file 1 of Imbalance of flight–freeze responses and their cellular correlates in the Nlgn3−/y rat model of autism
- Publication Year :
- 2022
- Publisher :
- figshare, 2022.
-
Abstract
- Additional file 1: Supplemental figures S1-S9. Figure S1. Nlgn3−/y rats display reduced classic freezing behaviour in a contextual fear conditioning paradigm. Figure S2. Freezing analysed as “paw immobility response” (all four paws unmoving but allowing for movement of head and neck). Figure S3. WT and Nlgn3−/y rats show similar activity in an open field, rotational platform & marble interaction tasks. Figure S4. Effect of repeated footshocks & thermal stimulus on WT and Nlgn3−/y rats. Figure S5. Intrinsic properties of PAG cells recorded from WT and Nlgn3−/y rats. Figure S6. Hyperexcitability of dorsal, but not ventral PAG neurons in 8-10 week old Nlgn3−/y rats. Figure S7. PAG LFPs during fear recall are significantly shorter duration in Nlgn3−/y rats. Figure S8. Defensive reactions were not elicited by electrical stimulation of primary somatosensory cortex in WT or Nlgn3−/y rats. Figure S9. Western blots showing lack expression of NLGN3 in Nlgn3−/y rats both in sensory cortex and periaqueductal grey.
Details
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....1e3f5e2c43e246826f2e98d934ccb5d6
- Full Text :
- https://doi.org/10.6084/m9.figshare.20336959.v1