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Severe fibrosis in hepatitis C virus-infected patients is associated with increased activity of the mannan-binding lectin (MBL)/MBL-associated serine protease 1 (MASP-1) complex
- Publication Year :
- 2007
- Publisher :
- Blackwell Science Inc, 2007.
-
Abstract
- Summary Mannan-binding lectin (MBL) binds microorganisms via interactions with glycans on the target surface. Bound MBL subsequently activates MBL-associated serine protease proenzymes (MASPs). A role for MBL in hepatitis C virus (HCV) infection had been indicated by previous studies examining MBL levels and polymorphisms in relation to disease progression and response to treatment. We undertook this study to investigate a possible relationship between disease progression and functional MBL/MASP-1 complex activity. A functional assay for MBL/MASP-1 complex activity was employed to examine serum samples from patients with chronic HCV infection, non-HCV liver disease and healthy controls. Intrapatient consistency of MBL/MASP-1 complex activity levels was assessed in sequential samples from a subgroup of patients. Median values of MBL/MASP-1 complex activity were higher in sera from patients with liver disease compared with healthy controls. MBL/MASP-1 complex activity levels correlate with severity of fibrosis after adjusting for confounding factors (P = 0·003). MBL/MASP-1 complex activity was associated more significantly with fibrosis than was MBL concentration. The potential role of MBL/MASP-1 complex activity in disease progression is worthy of further study to investigate possible mechanistic links.
- Subjects :
- Adult
Liver Cirrhosis
Male
Adolescent
Hepacivirus
Hepatitis C virus
Immunology
chemical and pharmacologic phenomena
medicine.disease_cause
Mannose-Binding Lectin
Virus
Flaviviridae
Liver disease
Immunopathology
Clinical Studies
medicine
Immunology and Allergy
Humans
Child
Mannan-binding lectin
Aged
Analysis of Variance
Chi-Square Distribution
biology
Lectin
Complement Pathway, Mannose-Binding Lectin
Confounding Factors, Epidemiologic
Middle Aged
biology.organism_classification
medicine.disease
bacterial infections and mycoses
Hepatitis C
Fatty Liver
Liver
Case-Control Studies
Child, Preschool
Mannose-Binding Protein-Associated Serine Proteases
biology.protein
Female
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....1e3e6cfaaf0cd692f31d4133e60ee1e9