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Full genome characterization of novel DS-1-like G9P[8] rotavirus strains that have emerged in Thailand
- Source :
- PLoS ONE, Vol 15, Iss 4, p e0231099 (2020), PLoS ONE
- Publication Year :
- 2020
- Publisher :
- Public Library of Science (PLoS), 2020.
-
Abstract
- The emergence and rapid spread of unusual DS-1-like intergenogroup reassortant rotaviruses having G1/3/8 genotypes have been recently reported from major parts of the world (Africa, Asia, Australia, Europe, and the Americas). During rotavirus surveillance in Thailand, three novel intergenogroup reassortant strains possessing the G9P[8] genotype (DBM2017-016, DBM2017-203, and DBM2018-291) were identified in three stool specimens from diarrheic children. In the present study, we determined and analyzed the full genomes of these three strains. On full-genomic analysis, all three strains were found to share a unique genotype constellation comprising both genogroup 1 and 2 genes: G9-P[8]-I2-R2-C2-M2-A2-N2-T2-E2-H2. Phylogenetic analysis demonstrated that each of the 11 genes of the three strains was closely related to that of emerging DS-1-like intergenogroup reassortant, human, and/or locally circulating human strains. Thus, the three strains were suggested to be multiple reassortants that had acquired the G9-VP7 genes from co-circulating Wa-like G9P[8] rotaviruses in the genetic background of DS-1-like intergenogroup reassortant (likely equine-like G3P[8]) strains. To our knowledge, this is the first description of emerging DS-1-like intergenogroup reassortant strains having the G9P[8] genotype. Our observations will add to the growing insights into the dynamic evolution of emerging DS-1-like intergenogroup reassortant rotaviruses through reassortment.
- Subjects :
- Rotavirus
0301 basic medicine
Thai People
Reassortment
medicine.disease_cause
Genome
Feces
Genotype
Ethnicities
Phylogeny
Data Management
Genetics
Multidisciplinary
Phylogenetic tree
Database and informatics methods
Sequence analysis
Phylogenetic Analysis
Genomics
Thailand
Phylogenetics
Viral evolution
Medicine
Research Article
Diarrhea
Computer and Information Sciences
Bioinformatics
Science
030106 microbiology
Nucleotide Sequencing
Genome, Viral
Biology
Research and Analysis Methods
Microbiology
Viral Evolution
Rotavirus Infections
03 medical and health sciences
Virology
medicine
Humans
Evolutionary Systematics
Molecular Biology Techniques
Sequencing Techniques
Molecular Biology
Genotyping
DNA sequence analysis
Taxonomy
Evolutionary Biology
Sequence Assembly Tools
Whole Genome Sequencing
Biology and Life Sciences
Computational Biology
Molecular Sequence Annotation
Genome Analysis
Organismal Evolution
030104 developmental biology
People and Places
Microbial Evolution
Population Groupings
Subjects
Details
- ISSN :
- 19326203
- Volume :
- 15
- Database :
- OpenAIRE
- Journal :
- PLOS ONE
- Accession number :
- edsair.doi.dedup.....1e2e05e691fdee5f4b2fc7f080b25b4c