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Olanzapine as Alternative Therapy for Patients With Haloperidol-Induced Extrapyramidal Symptoms: Results of a Multicenter, Collaborative Trial in Latin America
- Source :
- Journal of Clinical Psychopharmacology. 21:375-381
- Publication Year :
- 2001
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2001.
-
Abstract
- Conventional antipsychotic agents can induce extrapyramidal symptoms (EPS) that may be alleviated by switching patients to novel agents such as olanzapine. Patients with schizophrenia and related disorders (ICD-10) who were taking haloperidol (N = 94; mean dose = 12.7 mg/day) and had EPS (Simpson-Angus Scale [SAS] > 3) were directly switched to 6 weeks of open-label olanzapine treatment (mean dose = 11.4 mg/day). There were significant mean improvements (p
- Subjects :
- Adult
Male
Olanzapine
Dyskinesia, Drug-Induced
Adolescent
medicine.medical_treatment
Benzodiazepines
Extrapyramidal symptoms
Brief Psychiatric Rating Scale
medicine
Haloperidol
Humans
Pharmacology (medical)
Antipsychotic
Psychiatric Status Rating Scales
Positive and Negative Syndrome Scale
Pirenzepine
Middle Aged
Barnes Akathisia Scale
Psychiatry and Mental health
Latin America
Treatment Outcome
Anesthesia
Schizophrenia
Female
medicine.symptom
Psychology
Somnolence
Antipsychotic Agents
medicine.drug
Subjects
Details
- ISSN :
- 02710749
- Volume :
- 21
- Database :
- OpenAIRE
- Journal :
- Journal of Clinical Psychopharmacology
- Accession number :
- edsair.doi.dedup.....1e2d13a5d30cc48822c0cd4568cf4ca0