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The Role of Integrins in Reproduction
- Source :
- Proceedings of the Society for Experimental Biology and Medicine. 223:331-343
- Publication Year :
- 2000
- Publisher :
- Wiley, 2000.
-
Abstract
- Fertilization, implantation, and placentation are dynamic cellular events that require not only synchrony between the maternal environment and the embryo, but also complex cell-to-cell communication. This communication involves integrins, a large family of proteins involved in the attachment, migration, invasion, and control of cellular function. Over the past decade, investigators have learned that integrins participate in multiple reproductive events including fertilization, implantation, and placentation in many species. This review will describe: (i) the expression of integrins on gametes and during the establishment and development of the placenta; (ii) regulatory pathways for controlling expression of integrins in the uterus and developing placenta; (iii) the function of integrins as determined by null-mutations; and (iv) reproductive dysfunction in women related to inappropriate integrin expression in the uterus and/or placenta.
- Subjects :
- Integrins
media_common.quotation_subject
Integrin
Uterus
Biology
General Biochemistry, Genetics and Molecular Biology
Pregnancy
Placenta
medicine
Animals
Humans
Embryo Implantation
media_common
Reproduction
Placentation
Embryo
medicine.disease
Cell biology
medicine.anatomical_structure
Fertilization
Immunology
biology.protein
Female
Function (biology)
Subjects
Details
- ISSN :
- 15251373 and 00379727
- Volume :
- 223
- Database :
- OpenAIRE
- Journal :
- Proceedings of the Society for Experimental Biology and Medicine
- Accession number :
- edsair.doi.dedup.....1e2a7ac0f984704d800fe6090eec8545