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Molecular Events in the Natural History of Pancreatic Cancer
- Source :
- Trends in Cancer. 3:336-346
- Publication Year :
- 2017
- Publisher :
- Elsevier BV, 2017.
-
Abstract
- Pancreatic ductal adenocarcinoma (PDAC) is among the deadliest epithelial malignancies. Improvements in our understanding of PDAC carcinogenesis will hopefully improve its detection, management, and outcomes, as has been achieved with other malignancies. Here we review the literature on the natural history of PDAC, including its cell of origin, the initiating somatic mutational events, pathways deranged in the mature tumor, its biological heterogeneity, and the relationship of the primary tumor with metastases. We also suggest areas for further research and highlight translatable findings that are beginning to make clinical inroads.
- Subjects :
- 0301 basic medicine
Cancer Research
endocrine system diseases
Somatic cell
Cell of origin
Genomics
Biology
medicine.disease
Bioinformatics
medicine.disease_cause
Primary tumor
digestive system diseases
Pancreatic Neoplasms
Transcriptome
Natural history
03 medical and health sciences
030104 developmental biology
Oncology
Pancreatic cancer
Disease Progression
medicine
Cancer research
Humans
Carcinogenesis
Subjects
Details
- ISSN :
- 24058033
- Volume :
- 3
- Database :
- OpenAIRE
- Journal :
- Trends in Cancer
- Accession number :
- edsair.doi.dedup.....1e2392d38e46c7f4df2c3bc01e69628b