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Role of Long Noncoding RNAs in Parkinson’s Disease: Putative Biomarkers and Therapeutic Targets
- Source :
- Parkinson's Disease, Vol 2020 (2020), Parkinson's Disease
- Publication Year :
- 2020
- Publisher :
- Hindawi Limited, 2020.
-
Abstract
- Parkinson’s disease (PD) is a neurodegenerative disease characterized by bradykinesia, rigidity, and tremor. Age is the main risk factor. Long noncoding RNAs (lncRNAs) are novel RNA molecules of more than 200 nucleotides in length. They may be involved in the regulation of many pathological processes of PD. PD has a variety of pathophysiological mechanisms, including alpha-synuclein aggregate, mitochondrial dysfunction, oxidative stress, calcium homeostasis, axonal transport, and neuroinflammation. Among these, the impacts of lncRNAs on the pathogenesis and progression of PD need to be highlighted. lncRNAs may serve as putative biomarkers and therapeutic targets for the early diagnosis of PD. This study aimed to investigate the role of lncRNAs in various pathological processes of PD and the specific lncRNAs that might be used as putative diagnostic biomarkers and therapeutic targets of PD.
- Subjects :
- 0303 health sciences
Parkinson's disease
business.industry
Neuroscience (miscellaneous)
RNA
Review Article
Disease
Bioinformatics
medicine.disease
medicine.disease_cause
Pathogenesis
03 medical and health sciences
Psychiatry and Mental health
0302 clinical medicine
Medicine
Diagnostic biomarker
Neurology. Diseases of the nervous system
Neurology (clinical)
RC346-429
business
Pathological
030217 neurology & neurosurgery
Neuroinflammation
Oxidative stress
030304 developmental biology
Subjects
Details
- ISSN :
- 20420080 and 20908083
- Volume :
- 2020
- Database :
- OpenAIRE
- Journal :
- Parkinson's Disease
- Accession number :
- edsair.doi.dedup.....1e11897e217f1bb1a47e34513b81179c