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Potential Risk Factors Associated with Human Cystic Echinococcosis: Systematic Review and Meta-analysis
- Source :
- PLoS Neglected Tropical Diseases, Vol 10, Iss 11, p e0005114 (2016), Digital.CSIC. Repositorio Institucional del CSIC, instname, PLoS Neglected Tropical Diseases
- Publication Year :
- 2016
- Publisher :
- Public Library of Science (PLoS), 2016.
-
Abstract
- 15 páginas, 2 figuras, 2 tablas<br />Background Scientific literature on cystic echinococcosis (CE) reporting data on risk factors is limited and to the best of our knowledge, no global evaluation of human CE risk factors has to date been performed. This systematic review (SR) summarizes available data on statistically relevant potential risk factors (PRFs) associated with human CE.<br />Methodology/Principal Findings Database searches identified 1,367 papers, of which thirty-seven were eligible for inclusion. Of these, eight and twenty-nine were case-control and cross-sectional studies, respectively. Among the eligible papers, twenty-one were included in the meta-analyses. Pooled odds ratio (OR) were used as a measure of effect and separately analysed for the two study designs. PRFs derived from case-control studies that were significantly associated with higher odds of outcome were ªdog free to roamº (OR 5.23; 95% CI 2.45±11.14), ªfeeding dogs with visceraº (OR 4.69; 95% CI 3.02±7.29), ªslaughter at homeº (OR 4.67; 95% CI 2.02±10.78) or at ªslaughterhousesº (OR 2.7; 95% CI 1.15±6.3), ªdog ownershipº (OR 3.54; 95% CI 1.27±9.85), ªliving in rural areasº (OR 1.83; 95% CI 1.16±2.9) and ªlow incomeº (OR 1.68; 95% CI 1.02±2.76). Statistically significant PRFs from cross-sectional studies with higher odds of outcome were ªage >16 yearsº (OR 6.08; 95% CI 4.05±9.13), ªliving in rural areasº (OR 2.26; 95% CI 1.41±3.61), ªbeing femaleº (OR 1.38; 95% CI 1.06± 1.8) and ªdog ownershipº (OR 1.37; 95% CI 1.01±1.86). Conclusions/Significance Living in endemic rural areas, in which free roaming dogs have access to offal and being a dog-owner, seem to be among the most significant PRFs for acquiring this parasiticinfection. Results of data analysed here may contribute to our understanding of the PRFs for CE and may potentially be useful in planning community interventions aimed at controlling CE in endemic areas.<br />Conclusions/Significance Living in endemic rural areas, in which free roaming dogs have access to offal and being a dog-owner, seem to be among the most significant PRFs for acquiring this parasiticinfection. Results of data analysed here may contribute to our understanding of the PRFs for CE and may potentially be useful in planning community interventions aimed at controlling CE in endemic areas.<br />This research received funding from the European Community's Seventh Framework Programme under the grant agreement 602051 (Project HERACLES: Human cystic Echinococcosis ReseArch in CentraL and Eastern Societies; http://www.heracles-fp7.eu/).
- Subjects :
- Databases, Factual
Mathematical and Statistical Techniques
0302 clinical medicine
Risk Factors
Natural Resources
Surveys and Questionnaires
Medicine and Health Sciences
030212 general & internal medicine
Geographic Areas
Mammals
Geography
lcsh:Public aspects of medicine
Age Factors
1. No poverty
3. Good health
Infectious Diseases
Helminth Infections
Research Design
Vertebrates
Physical Sciences
Water Resources
Female
Statistics (Mathematics)
Research Article
Neglected Tropical Diseases
lcsh:Arctic medicine. Tropical medicine
lcsh:RC955-962
030231 tropical medicine
Research and Analysis Methods
03 medical and health sciences
Dogs
Sex Factors
Echinococcosis
Parasitic Diseases
Animals
Humans
Statistical Methods
Ecology and Environmental Sciences
Organisms
Public Health, Environmental and Occupational Health
Biology and Life Sciences
lcsh:RA1-1270
Tropical Diseases
Rural Areas
Echinococcus
Cross-Sectional Studies
Case-Control Studies
Amniotes
Earth Sciences
Mathematics
Meta-Analysis
Subjects
Details
- ISSN :
- 19352735
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- PLOS Neglected Tropical Diseases
- Accession number :
- edsair.doi.dedup.....1e0b07e68ca0a1f78fcbb2e3262cd5f8