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L-dihydroxyphenylalanine and complex I deficiency in Parkinson's disease brain
- Source :
- Movement disorders : official journal of the Movement Disorder Society. 10(3)
- Publication Year :
- 1995
-
Abstract
- There is evidence for a 37% deficiency of complex I activity in Parkinson's disease (PD), which appears to be specific for PD amongst parkinsonian syndromes and selective for the substantia nigra within the central nervous system. Rat studies have shown that, in the context of a normal nigrostriatal dopaminergic cell population, L-dihydroxyphenylalanine (L-dopa) causes a reversible 25% defect of complex I activity in nigral and striatal tissue. Analysis of striatal tissue from PD patients after prolonged exposure to high-dose L-dopa does not show such a defect. Results of these and other studies suggest that L-dopa therapy does not cause complex I deficiency in PD striatum. However, it cannot be excluded that, in the particular environment of the PD substantia nigra, L-dopa may enhance a preexisting complex I defect.
- Subjects :
- Male
medicine.medical_specialty
Parkinson's disease
Population
Respiratory chain
Substantia nigra
Context (language use)
Striatum
Levodopa
Dopaminergic Cell
Internal medicine
Neural Pathways
NAD(P)H Dehydrogenase (Quinone)
Medicine
Humans
education
Aged
Aged, 80 and over
education.field_of_study
business.industry
Putamen
Brain
Parkinson Disease
Middle Aged
medicine.disease
nervous system diseases
Substantia Nigra
Endocrinology
nervous system
Neurology
Nerve Degeneration
Female
Neurology (clinical)
business
Subjects
Details
- ISSN :
- 08853185
- Volume :
- 10
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Movement disorders : official journal of the Movement Disorder Society
- Accession number :
- edsair.doi.dedup.....1dfc575f3faf0ebbda0ca056aa22aae7