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Hepatic arterial infusion combined with systemic chemotherapy induced complete response of metachronous liver metastases after resection of pancreatic insulinoma
- Source :
- Clinical Journal of Gastroenterology. 6:496-499
- Publication Year :
- 2013
- Publisher :
- Springer Science and Business Media LLC, 2013.
-
Abstract
- Insulinomas are the most common functioning pancreatic neuroendocrine tumors (PNETs). We herein present the case of a 5-year survivor with insulinoma after complete response of postoperative liver metastases to hepatic arterial infusion combined with systemic chemotherapy. A 58-year-old woman was admitted to our hospital following loss of consciousness. Examination revealed a pancreatic tumor, and she underwent distal pancreatectomy following diagnosis of insulinoma. Superparamagnetic iron oxide magnetic resonance imaging (SPIO-MRI) revealed multiple liver metastases 3 months after surgery. Therefore, we performed hepatic arterial infusion of 5-fluorouracil (5-FU) combined with systemic gemcitabine infusion. We observed complete ablation of all metastatic liver nodules after 11 cycles of the chemotherapy using MRI. We continued this chemotherapy regimen for 20 cycles, and the patient remains alive without any recurrence 7 years after surgery.
- Subjects :
- Oncology
Pancreatic Insulinoma
Chemotherapy
medicine.medical_specialty
business.industry
medicine.medical_treatment
Gastroenterology
General Medicine
Neuroendocrine tumors
medicine.disease
Chemotherapy regimen
Gemcitabine
Hepatic arterial infusion
Pancreatic tumor
Internal medicine
medicine
Radiology
business
Insulinoma
medicine.drug
Subjects
Details
- ISSN :
- 18657265 and 18657257
- Volume :
- 6
- Database :
- OpenAIRE
- Journal :
- Clinical Journal of Gastroenterology
- Accession number :
- edsair.doi.dedup.....1df074f8b2647e46f571f441819de50d