Back to Search
Start Over
Triclosan-containing fluoride toothpaste on clinical parameters and osteo-inflammatory mediators when applied in a stent during experimental peri-implant mucositis in smokers
- Source :
- Clinical oral implants research. 30(2)
- Publication Year :
- 2017
-
Abstract
- Objectives To determine the effect of triclosan-containing fluoride toothpaste on the clinical parameters and the osteo-immunoinflammatory mediators in the peri-implant fluid when applied in a stent during experimental peri-implant mucositis in smokers. Materials and methods Twenty-six smokers with an implant-supported crown were enrolled in this double-blind, randomized, crossover study. During the two 3-week periods without mechanical toothbrushing (washout period: 30 days), patients were randomly assigned to triclosan/fluoride (n:13) or fluoride toothpaste (n:13), three times/day. Clinical and immunoenzymatic assays were performed at baseline, 3, 7, 14 and 21 days. Results Both groups showed increase in the Plaque Index throughout the study (p = 0.001), without inter-group differences at 21 days (p > 0.05). No intra- or inter-group differences were observed for IFN-γ, IL10, IL-1β, IL8, IL-17, IL-6, TNF-α, MMP-2, MMP-9, TGF-β, OC, OPN, ICTP, OPG and RANKL (p > 0.05). However, the RANKL/OPG ratio was significantly higher in fluoride toothpaste-treated sites when compared to triclosan/fluoride-treated sites at the end of period without mechanical toothbrushing, on the 21st day (p = 0.041). Conclusion Triclosan-containing toothpaste favorably modulated osteo-immunoinflammatory mediators during the experimental peri-implant mucositis in smokers, decreasing the ratio of RANKL/OPG.
- Subjects :
- musculoskeletal diseases
Mucositis
medicine.medical_specialty
Peri-implant mucositis
business.product_category
medicine.medical_treatment
0206 medical engineering
02 engineering and technology
Gastroenterology
03 medical and health sciences
chemistry.chemical_compound
Fluorides
Random Allocation
0302 clinical medicine
Double-Blind Method
Internal medicine
medicine
Humans
Toothpaste
Smokers
biology
business.industry
Anti-Inflammatory Agents, Non-Steroidal
Stent
030206 dentistry
medicine.disease
020601 biomedical engineering
Crossover study
Triclosan
chemistry
RANKL
biology.protein
Stents
Oral Surgery
business
Fluoride
Toothpastes
Subjects
Details
- ISSN :
- 16000501
- Volume :
- 30
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Clinical oral implants research
- Accession number :
- edsair.doi.dedup.....1de7377f6c09bb43aba5498f67ff5e90