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High attenuation areas on chest computed tomography in community-dwelling adults: the MESA study
- Source :
- European Respiratory Journal. 48:1442-1452
- Publication Year :
- 2016
- Publisher :
- European Respiratory Society (ERS), 2016.
-
Abstract
- Evidence suggests that lung injury, inflammation and extracellular matrix remodelling precede lung fibrosis in interstitial lung disease (ILD). We examined whether a quantitative measure of increased lung attenuation on computed tomography (CT) detects lung injury, inflammation and extracellular matrix remodelling in community-dwelling adults sampled without regard to respiratory symptoms or smoking.We measured high attenuation areas (HAA; percentage of lung voxels between −600 and −250 Hounsfield Units) on cardiac CT scans of adults enrolled in the Multi-Ethnic Study of Atherosclerosis.HAA was associated with higher serum matrix metalloproteinase-7 (mean adjusted difference 6.3% per HAA doubling, 95% CI 1.3–11.5), higher interleukin-6 (mean adjusted difference 8.8%, 95% CI 4.8–13.0), lower forced vital capacity (FVC) (mean adjusted difference −82 mL, 95% CI −119–−44), lower 6-min walk distance (mean adjusted difference −40 m, 95% CI −1–−80), higher odds of interstitial lung abnormalities at 9.5 years (adjusted OR 1.95, 95% CI 1.43–2.65), and higher all cause-mortality rate over 12.2 years (HR 1.58, 95% CI 1.39–1.79).High attenuation areas are associated with biomarkers of inflammation and extracellular matrix remodelling, reduced lung function, interstitial lung abnormalities, and a higher risk of death among community-dwelling adults.
- Subjects :
- Adult
Male
Pulmonary and Respiratory Medicine
medicine.medical_specialty
Vital capacity
Lung injury
03 medical and health sciences
FEV1/FVC ratio
0302 clinical medicine
Internal medicine
Hounsfield scale
medicine
Humans
030212 general & internal medicine
Respiratory system
Exercise
Lung
Aged
Proportional Hazards Models
Inflammation
Interleukin-6
Proportional hazards model
business.industry
Smoking
Interstitial lung disease
Middle Aged
medicine.disease
Fibrosis
Extracellular Matrix
C-Reactive Protein
medicine.anatomical_structure
030228 respiratory system
Spirometry
Matrix Metalloproteinase 7
Cardiology
Female
Radiography, Thoracic
Radiology
Lung Diseases, Interstitial
Tomography, X-Ray Computed
business
Biomarkers
Subjects
Details
- ISSN :
- 13993003 and 09031936
- Volume :
- 48
- Database :
- OpenAIRE
- Journal :
- European Respiratory Journal
- Accession number :
- edsair.doi.dedup.....1dd8bb19efe946affe31c83c4fd48bcd