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Angiogenic T-Cells and Putative Endothelial Progenitor Cells in Hypertension-Related Cerebral Small Vessel Disease
- Source :
- Stroke, 43(1), 256-U509. LIPPINCOTT WILLIAMS & WILKINS
- Publication Year :
- 2012
- Publisher :
- LIPPINCOTT WILLIAMS & WILKINS, 2012.
-
Abstract
- Background and Purpose— Cerebral small vessel disease (CSVD) may be caused by endothelial dysfunction, whereas endothelial progenitor cells (EPC) may attenuate endothelial dysfunction. Their vitality is lower in CSVD. A subset of lymphocytes, angiogenic T-cells, is capable to stimulate EPC function. The purpose of our study was to explore the relation between CSVD manifestations, angiogenic T-cells, and EPC in hypertensive patients with CSVD. Methods— We compared 32 essential hypertensive patients with CSVD (white matter lesions, asymptomatic lacunar infarcts, or microbleeds on 1.5-Tesla MRI) to 29 age-matched and sex-matched hypertensive controls. We counted angiogenic T-cells (CD3 + /CD31 + /CD184 + ) and putative EPC (CD31 + /CD34 + /CD45 - /KDR + ) by flow cytometry and determined EPC vitality by in vitro cluster formation. Results— Putative EPC numbers were lower in hypertensive individuals with CSVD than in those without (10±7 . 10 3 /mL versus 13±6 . 10 3 /mL [median±interquartile range]; P =0.011). Angiogenic T-cell numbers were also lower in hypertensive individuals with CSVD than in those without (0.56±0.25 . 10 9 /mL versus 0.78±0.50 . 10 9 /mL; P =0.008). Higher angiogenic T-cell numbers independently related to absence of CSVD (odds ratio, 0.088; 95% confidence interval, 0.012–0.627). Conclusions— Our data suggest that angiogenic T-cells and putative EPC independently relate to radiological CSVD manifestations in hypertensive patients.
- Subjects :
- Adult
Male
CD31
Pathology
medicine.medical_specialty
hypertension
Endothelium
CD3
CD34
Asymptomatic
Flow cytometry
Humans
Medicine
Longitudinal Studies
Endothelial dysfunction
Progenitor cell
T-lymphocytes
endothelial progenitor cells
Advanced and Specialized Nursing
biology
medicine.diagnostic_test
business.industry
Stem Cells
white matter lesions
leukoaraiosis
Endothelial Cells
Flow Cytometry
medicine.disease
medicine.anatomical_structure
Cerebral Small Vessel Diseases
biology.protein
Female
Endothelium, Vascular
Neurology (clinical)
medicine.symptom
Cardiology and Cardiovascular Medicine
business
Subjects
Details
- Language :
- English
- ISSN :
- 15244628 and 00392499
- Volume :
- 43
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Stroke
- Accession number :
- edsair.doi.dedup.....1dcec884f9a7e5bea0563adedffef778