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Biphasic time course of brain water ADC observed during the first month of life in term neonates with severe perinatal asphyxia is indicative of poor outcome at 3 years
- Source :
- Magnetic Resonance Imaging, Magnetic Resonance Imaging, Elsevier, 2011, 29 (2), pp.194-201. ⟨10.1016/j.mri.2010.09.005⟩, Magnetic Resonance Imaging, Elsevier, 2011, 29 (2), pp.194-201. 〈10.1016/j.mri.2010.09.005〉
- Publication Year :
- 2011
- Publisher :
- Elsevier BV, 2011.
-
Abstract
- International audience; Abstract: In severe perinatal asphyxia, the prognostic value of apparent diffusion coefficient (ADC) measurements is still open to question. We hypothesized that temporal and anatomical changes of brain ADC values occurring early after the hypoxic ischemic insult could predict the outcome at 36 months. To demonstrate this, mean ADC values were calculated for 16 brain structures in 59 term neonates who underwent an MR examination during the first month of life. Neonates were divided into two groups according to their 36-month outcome: unfavorable (death/severe disability) or favorable outcome. ADC values were plotted against age at scan. In neonates with favorable outcomes (n=32), ADC values were constant over the study period. In babies with unfavorable outcomes (n=27), ADCs exhibited two different patterns. In infratentorial structures, ADCs were constant and normal. In supratentorial areas, ADCs followed a biphasic temporal evolution: ADC values were at their lowest at day 2, showed a rapid increase until Days 5-7, and were thereafter similar to those of neonates with favorable outcomes. Using receiver operating characteristic analysis, during the first 3-5 days of life, all neonates with decreased ADC had an unfavorable outcome. These temporal and anatomical changes of ADC values imply that individual prognosis of asphyxiated neonates can only be predicted by measurement of ADC in supratentorial areas within the first 3-5 days of life.
- Subjects :
- Male
medicine.medical_specialty
Pediatrics
Diffusion magnetic resonance imaging
Body water
Biomedical Engineering
Biophysics
Brain water
Sensitivity and Specificity
Hypoxic Ischemic Encephalopathy
03 medical and health sciences
0302 clinical medicine
Body Water
Hypoxic-ischemic encephalopathy
030225 pediatrics
Internal medicine
Image Interpretation, Computer-Assisted
[INFO.INFO-IM]Computer Science [cs]/Medical Imaging
Humans
Medicine
Effective diffusion coefficient
Radiology, Nuclear Medicine and imaging
Asphyxia Neonatorum
[ INFO.INFO-IM ] Computer Science [cs]/Medical Imaging
Receiver operating characteristic analysis
business.industry
Infant, Newborn
Brain
Reproducibility of Results
Newborn
Prognosis
Term neonates
medicine.disease
Perinatal asphyxia
body regions
Time course
Cardiology
Female
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 0730725X
- Volume :
- 29
- Database :
- OpenAIRE
- Journal :
- Magnetic Resonance Imaging
- Accession number :
- edsair.doi.dedup.....1db0e003e17e4104618c196b5ca6a677