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Highway driving performance and cognitive functioning the morning after bedtime and middle-of-the-night use of gaboxadol, zopiclone and zolpidem
- Source :
- Journal of Sleep Research, 18(4), 387-396. Wiley
- Publication Year :
- 2009
-
Abstract
- Gaboxadol is a selective extrasynaptic GABA(A) receptor agonist previously in development for the treatment of insomnia. Due to its short half-life (1.5-2 h) it is expected to be free from residual effects the next morning. The present study assessed the residual effects of evening and middle-of-the-night administration of 15 mg of gaboxadol on cognitive, psychomotor and driving performance. Twenty-eight healthy volunteers entered the study with 25 (12 women; mean age 31.4 years) completing a double-blind, placebo-controlled, active-referenced five-way cross-over study. Each treatment night subjects ingested one capsule at 23:00 hours and one at 04:00 hours. Treatments were placebo at both times, 15 mg gaboxadol or 7.5 mg zopiclone followed by placebo, and placebo followed by 15 mg gaboxadol or 10 mg zolpidem. Effects on cognition and psychomotor performance were assessed between 07:30 and 08:30 hours and on driving between 09:00 and 10:00 hours. Driving, as measured by standard deviation of lateral position in an on-the-road driving test, was almost significantly (P
- Subjects :
- Adult
Male
Zolpidem
Automobile Driving
Evening
Pyridines
Cognitive Neuroscience
Poison control
Neuropsychological Tests
Placebo
Bedtime
Drug Administration Schedule
Piperazines
Behavioral Neuroscience
Young Adult
Cognition
Double-Blind Method
Orientation
Sleep Initiation and Maintenance Disorders
medicine
Reaction Time
Humans
Attention
GABA Agonists
Postural Balance
Morning
Zopiclone
Cross-Over Studies
Retention, Psychology
General Medicine
Isoxazoles
Affect
Memory, Short-Term
Anesthesia
Female
Psychology
Arousal
Azabicyclo Compounds
Gaboxadol
Psychomotor Performance
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 09621105
- Volume :
- 18
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Journal of Sleep Research
- Accession number :
- edsair.doi.dedup.....1d9b2be28755957e259e30b4ea5fea52