AN INVESTIGATION OF POLYMORPHISM IN THE INTERLEUKIN-10 GENE PROMOTER

Authors :: Paul J. Sinnott
Mark Lazarus
Ian V. Hutchinson
D Sankaran
D. M. Williams
D. M. Turner
Source :: European Journal of Immunogenetics. 24:1-8
Publication Year :: 1997
Publisher :: Wiley, 1997.
Abstract: SUMMARY Interleukin-10 (IL-10) has been described as an anti-inflammatory cytokine and B-cell proliferation factor and has been implicated in autoimmunity, tumorigenesis and transplantation tolerance. We have identified three single base pair substitutions in the IL-10 gene promoter and have investigated whether this polymorphism correlates with IL-10 protein production in vitro.