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Association of ALOX12 and ALOX15 gene polymorphisms with age at menarche and natural menopause in Chinese women
- Source :
- Menopause (New York, N.Y.). 19(9)
- Publication Year :
- 2012
-
Abstract
- OBJECTIVE: Lipoxygenase (LOX) is one of the major metabolic enzymes for arachidonic acid, which has been reported to be associated with many postmenopausal and many hormone-related diseases. In rats, selective inhibition of the LOX pathway led to defective ovulation. However, little is known about the association of the LOX-related genes with menstruation in women. In this study, we investigated the possible association of two key gene (ALOX12 and ALOX15) polymorphisms with age of menarche and menopause in Chinese women. METHODS: Six tagging single nucleotide polymorphisms (SNPs) of ALOX12 and five SNPs of ALOX15 were genotyped. The association of single SNPs and haplotypes in two candidate genes and age at menarche (AAM) variation was tested in 401 Chinese nuclear families using the quantitative transmissing disequilibrium test. Furthermore, the association between these SNPs and haplotypes and age at natural menopause (AANM) in 710 postmenopausal Chinese women was measured. RESULTS: Using family- and population-based statistical procedures, significant association was found between SNPs rs312462 in ALOX12 and AAM in nuclear families (P = 0.043), and three SNPs (rs2292350, rs312470, and rs312462) in ALOX12 were significantly associated with AANM in postmenopausal women (P = 0.012, P = 0.045, and P = 0.033, respectively). Haplotype analyses corroborated our single SNP results (P = 0.030). However, we failed to find a significant association between ALOX15 gene polymorphisms and AAM as well as AANM (P > 0.05). CONCLUSIONS: Our present results suggest that genetic variations in ALOX12 are associated with both the onset and cessation of menstruation in Chinese women living in Shanghai.
- Subjects :
- Adult
Male
Linkage disequilibrium
Candidate gene
China
Population
Physiology
Mothers
Single-nucleotide polymorphism
Arachidonate 12-Lipoxygenase
Polymorphism, Single Nucleotide
Linkage Disequilibrium
Nuclear Family
Fathers
Asian People
Medicine
SNP
Arachidonate 15-Lipoxygenase
Humans
education
Aged
Aged, 80 and over
Menarche
education.field_of_study
Polymorphism, Genetic
business.industry
Haplotype
Age Factors
Obstetrics and Gynecology
Middle Aged
medicine.disease
Menopause
Haplotypes
Female
business
Subjects
Details
- ISSN :
- 15300374
- Volume :
- 19
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- Menopause (New York, N.Y.)
- Accession number :
- edsair.doi.dedup.....1d86074398883dfd13b11c313b6ce63e