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Ocular size and shape in lens-induced Myopization in young Guinea pigs
- Source :
- BMC Ophthalmology, BMC Ophthalmology, Vol 19, Iss 1, Pp 1-8 (2019)
- Publication Year :
- 2019
- Publisher :
- BioMed Central, 2019.
-
Abstract
- Background Lens-induced myopization in guinea pigs has been used as model for the process of myopization in humans. It has not been explored yet whether the change in globe shape in eyes undergoing myopization is similar in experimental myopia in guinea pigs and in clinical myopia in patients. Methods The study included 70 guinea pigs (age:2–3 weeks) equally divided into a study group with lens-induced myopization for 5 weeks, and a control group wearing goggles with no refractive power. The globe diameters were measured using a microcaliper after enucleation. Results The horizontal globe diameter (9.19 ± 0.15 mm versus 9.15 ± 0.18 mm; P = 0.25) and vertical globe diameter (9.02 ± 0.11 mm versus 8.99 ± 0.14 mm; P = 0.29) did not differ significantly between the study group and control group. The sagittal diameter was significantly longer in the study group (8.96 ± 0.15 mm versus 8.84 ± 0.14 mm; P = 0.001). While the vertical and horizontal globe diameters were correlated with each other in a ratio of approximately 1:1 (non-standardized regression coefficient B:0.94;95% confidence interval (CI):0.73,1.15), the steepness of the regression lines of the associations of both diameters with the sagittal diameter were flatter (horizontal to sagittal diameter: B: 0.64; 95% CI: 0.44,0.83; vertical to sagittal diameter:B:0.55;95% CI:0.41,0.69). Correspondingly, the ratios of horizontal-to-sagittal globe diameter and of vertical-to-sagittal globe diameter decreased (P
- Subjects :
- medicine.medical_specialty
Refractive error
Ocular elongation
Enucleation
Globe diameter
Guinea Pigs
03 medical and health sciences
Axial length
0302 clinical medicine
Lens-induced axial elongation
lcsh:Ophthalmology
Ophthalmology
High myopia
Myopia
Medicine
Animals
Sagittal diameter
In patient
business.industry
Eye diameter
General Medicine
medicine.disease
Axial elongation
Sagittal plane
Axial Length, Eye
Disease Models, Animal
medicine.anatomical_structure
lcsh:RE1-994
Lens (anatomy)
030221 ophthalmology & optometry
Vertical diameter
Regression Analysis
business
030217 neurology & neurosurgery
Research Article
Eye size
Subjects
Details
- Language :
- English
- ISSN :
- 14712415
- Volume :
- 19
- Database :
- OpenAIRE
- Journal :
- BMC Ophthalmology
- Accession number :
- edsair.doi.dedup.....1d70af5154637b4362e5e42504f6caa2