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Recommendations for the use of COVID-19 vaccines in patients with immune-mediated kidney diseases
- Source :
- Nephrology Dialysis Transplantation, Nephrology Dialysis Transplantation, 36(7), 1160-1168. OXFORD UNIV PRESS
- Publication Year :
- 2021
- Publisher :
- OXFORD UNIV PRESS, 2021.
-
Abstract
- Coronavirus disease 2019 (COVID-19) vaccine platforms are becoming available and are the most promising strategy to curb the spread of severe acute respiratory syndrome coronavirus 2 infections. However, numerous uncertainties exist regarding the pros and cons of vaccination, especially in patients with (immune-mediated) kidney diseases on immunosuppressive drugs. Here, members of the Immunonephrology Working Group of the European Renal Association–European Dialysis and Transplant Association discuss 13 frequently asked questions regarding the safety and efficacy of the most promising vaccine candidates. Post-marketing surveillance should be performed to estimate the rate of vaccine response (humoral and cellular) of different vaccine platforms and disease activity following the administration of COVID-19 vaccines. Some of the candidates induce signalling pathways, which also promote autoimmune kidney diseases, e.g. type I interferons in systemic lupus erythematosus. Efficacy estimates would thus far favour the use of selected COVID-19 vaccines, such as BNT162b2, mRNA-1273 or Gam-COVID-Vac. Humoral immune response after vaccination should be monitored using appropriate assays. Even in the absence of neutralizing antibodies, patients might be protected by a sufficient cellular immune response capable of reducing the severity of COVID-19. A reduced vaccine response after the use of CD20-depleting agents is anticipated and it is particularly important to discuss strategies to improve vaccine response with these patients. Distancing and shielding measures remain important, as not all vaccines fully protect from coronavirus infection. In-depth information about the most pressing vaccine questions is essential to reduce vaccine hesitancy of patients.
- Subjects :
- medicine.medical_treatment
Disease
030204 cardiovascular system & hematology
medicine.disease_cause
immune response
03 medical and health sciences
0302 clinical medicine
Immune system
Immunity
vaccine
medicine
030212 general & internal medicine
AcademicSubjects/MED00340
Dialysis
Coronavirus
Transplantation
Kidney
Review (On Invitation Only)
biology
business.industry
COVID-19
immunity
Vaccination
medicine.anatomical_structure
Nephrology
Immunology
biology.protein
Antibody
business
glomerulonephritis
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Nephrology Dialysis Transplantation, Nephrology Dialysis Transplantation, 36(7), 1160-1168. OXFORD UNIV PRESS
- Accession number :
- edsair.doi.dedup.....1d64edeadb7f6979f665a29cb784acb3