Back to Search
Start Over
Multivalent polymers displaying M2 macrophage-targeting peptides improve target binding avidity and serum stability
- Source :
- ACS biomaterials scienceengineering. 3(9)
- Publication Year :
- 2018
-
Abstract
- Tumor-associated macrophages (TAMs) display a spectrum of phenotypes ranging from pro-tumoral/anti-inflammatory “M2-like” to anti-tumoral/pro-inflammatory “M1-like” subtypes and, consequently, high intratumoral M2-to-M1 ratios are typically indicative of poor disease prognosis. Cancer immunotherapies that selectively modulate M2-like TAMs, enabling reversal of the M2-to-M1 ratio, represent a promising anti-cancer intervention but are difficult to implement due to the lack of effective targeting systems. In this study, we report the development of high avidity, M2 macrophage-selective targeted drug delivery platforms based on M2 macrophage-targeting peptides (M2pep) grafted onto poly(N-(2-hydroxypropyl) methacrylamide). Furthermore, these M2pep-grafted polymers also exhibit improved serum stability along with M2 macrophage-selective toxicity.
- Subjects :
- 0301 basic medicine
chemistry.chemical_classification
Biomedical Engineering
Cancer
02 engineering and technology
Polymer
021001 nanoscience & nanotechnology
M2 Macrophage
medicine.disease
Molecular biology
Phenotype
Article
Biomaterials
03 medical and health sciences
chemistry.chemical_compound
030104 developmental biology
chemistry
Targeted drug delivery
Cancer research
medicine
Methacrylamide
Avidity
0210 nano-technology
Target binding
Subjects
Details
- ISSN :
- 23739878
- Volume :
- 3
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- ACS biomaterials scienceengineering
- Accession number :
- edsair.doi.dedup.....1d57fe820cd9e56cca244c3e6dea8749