Back to Search
Start Over
The role of epigenetics and long noncoding RNA MIAT in neuroendocrine prostate cancer
- Source :
- Epigenomics. 8(5)
- Publication Year :
- 2016
-
Abstract
- Neuroendocrine prostate cancer (NEPC) is the most lethal prostatic neoplasm. NEPC is thought to originate from the transdifferentiation of AR-positive adenocarcinoma cells. We have previously shown that an epigenetic/noncoding interactome (ENI) orchestrates cancer cells’ plasticity, thereby allowing the emergence of metastatic, drug-resistant neoplasms. The primary objective of this manuscript is to discuss evidence indicating that some components of the ENI (Polycomb genes, miRNAs) play a key role in NEPC initiation and progression. Long noncoding RNAs represent vast and largely unexplored component of the ENI. Their role in NEPC has not been investigated. We show preliminary evidence indicating that a lncRNA (MIAT) is selectively upregulated in NEPCs and might interact with Polycomb genes. Our results indicate that long noncoding RNAs can be exploited as new biomarkers and therapeutic targets for NEPC.
- Subjects :
- 0301 basic medicine
Male
Cancer Research
Polycomb-Group Proteins
Biology
Bioinformatics
Interactome
Epigenesis, Genetic
03 medical and health sciences
Prostate cancer
microRNA
Genetics
medicine
Biomarkers, Tumor
Humans
Epigenetics
Gene
Prostatic Neoplasms
medicine.disease
Long non-coding RNA
Gene Expression Regulation, Neoplastic
Neuroendocrine Tumors
030104 developmental biology
Cancer cell
Cell Transdifferentiation
Cancer research
Adenocarcinoma
RNA, Long Noncoding
Subjects
Details
- ISSN :
- 1750192X
- Volume :
- 8
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Epigenomics
- Accession number :
- edsair.doi.dedup.....1d57049323e4eb127855f6ce128b8d6a