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Improved Vaccine Protection from Simian AIDS by the Addition of Nonstructural Simian Immunodeficiency Virus Genes
- Source :
- The Journal of Immunology. 176:85-96
- Publication Year :
- 2006
- Publisher :
- The American Association of Immunologists, 2006.
-
Abstract
- An HIV-1 vaccine able to induce broad CD4+ and CD8+ T cell responses may provide long-term control of viral replication. In this study we directly assess the relative benefit of immunization with vaccines expressing three structural Ags (Gag, Pol, and Env), three early regulatory proteins (Rev, Tat, and Nef), or a complex vaccine expressing all six Ags. The simultaneous administration of all six Ags during vaccination resulted in Ag competition manifested by a relative reduction of CD8+ T cell and lymphoproliferative responses to individual Ags. Despite the Ag competition, vaccination with all six Ags resulted in a delay in the onset and a decrease in the extent of acute viremia after mucosal challenge exposure to highly pathogenic SIVmac251. Reduced levels of acute viremia correlated with lower post-set point viremia and long-term control of infection. In immunized animals, virus-specific CD4+ T cell and lymphoproliferative responses were preserved during acute viremia, and the maintenance of these responses predicted the long-term virological outcome. Taken together, these results suggest that the breadth of the immune response is probably more important than high frequency responses to a limited number of epitopes. These data provide the first clear evidence of the importance of nonstructural HIV Ags as components of an HIV-1 vaccine.
- Subjects :
- Genes, Viral
T-Lymphocytes
T cell
Immunology
Simian Acquired Immunodeficiency Syndrome
Viremia
Biology
medicine.disease_cause
Immune system
medicine
Animals
Immunology and Allergy
Antigens, Viral
SAIDS Vaccines
virus diseases
Simian immunodeficiency virus
medicine.disease
Macaca mulatta
Virology
Vaccination
medicine.anatomical_structure
Viral replication
Simian AIDS
Simian Immunodeficiency Virus
CD8
Subjects
Details
- ISSN :
- 15506606 and 00221767
- Volume :
- 176
- Database :
- OpenAIRE
- Journal :
- The Journal of Immunology
- Accession number :
- edsair.doi.dedup.....1d504268ff5673a40b9251f34bf3ffcc