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A Review on Phytochemicals of the Genus Maytenus and Their Bioactive Studies
- Source :
- Molecules, Molecules, Vol 26, Iss 4563, p 4563 (2021)
- Publication Year :
- 2021
- Publisher :
- MDPI, 2021.
-
Abstract
- The genus Maytenus is a member of the Celastraceae family, of which several species have long been used in traditional medicine. Between 1976 and 2021, nearly 270 new compounds have been isolated and elucidated from the genus Maytenus. Among these, maytansine and its homologues are extremely rare in nature. Owing to its unique skeleton and remarkable bioactivities, maytansine has attracted many synthetic endeavors in order to construct its core structure. In this paper, the current status of the past 45 years of research on Maytenus, with respect to its chemical and biological activities are discussed. The chemical research includes its structural classification into triterpenoids, sesquiterpenes and alkaloids, along with several chemical synthesis methods of maytansine or maytansine fragments. The biological activity research includes activities, such as anti-tumor, anti-bacterial and anti-inflammatory activities, as well as HIV inhibition, which can provide a theoretical basis for the better development and utilization of the Maytenus.
- Subjects :
- Anti-HIV Agents
Phytochemicals
Human immunodeficiency virus (HIV)
Anti-Inflammatory Agents
Pharmaceutical Science
Organic chemistry
Review
medicine.disease_cause
alkaloids
01 natural sciences
Analytical Chemistry
Celastraceae
Structure-Activity Relationship
Triterpenoid
QD241-441
synthesis of maytansine
Genus
sesquiterpenes
Drug Discovery
medicine
Humans
Maytansine
Physical and Theoretical Chemistry
Chemical research
Plants, Medicinal
biology
Traditional medicine
Molecular Structure
010405 organic chemistry
Maytenus
Structural classification
triterpenoids
biology.organism_classification
Antineoplastic Agents, Phytogenic
Triterpenes
0104 chemical sciences
Anti-Bacterial Agents
010404 medicinal & biomolecular chemistry
Chemistry (miscellaneous)
Molecular Medicine
Subjects
Details
- Language :
- English
- ISSN :
- 14203049
- Volume :
- 26
- Issue :
- 15
- Database :
- OpenAIRE
- Journal :
- Molecules
- Accession number :
- edsair.doi.dedup.....1d3c99bc1f0cd8be12af8c6bff2dcfb0