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Adult asthma is associated with an increased risk of herpes zoster: A population-based cohort study
- Source :
- The Journal of asthma : official journal of the Association for the Care of Asthma. 54(3)
- Publication Year :
- 2016
-
Abstract
- Objective: The objective of this study was to determine whether a new diagnosis of asthma is associated with a later diagnosis of herpes zoster (HZ) in a nationwide, retrospective, non-age limited, population-based cohort. Methods: We used data from the National Health Insurance Research Database in Taiwan. The asthma group consisted of all 40 069 patients in the database with newly diagnosed asthma and using asthma medications from 2000 through 2005. The nonasthma group comprised 40 069 age- and sex-matched patients without any asthma diagnosis. Cox proportional hazards regression analysis was applied to calculate the hazard ratio of HZ in the patients with asthma relative to those without asthma. Results: During a mean follow-up period of 8.77 years, the risk of HZ was 1.48-fold higher in the asthma group compared with that in the nonasthma group after adjustment for sex, age, comorbidities, inhaled and systemic corticosteroid use, and annual outpatient department visits to dermatologists. Additional stratified analyses revealed that the risk of HZ was significantly higher in patients of both sexes and those aged older than 21 years. Conclusions: Newly diagnosed adult patients with asthma have a significantly higher risk of developing HZ than do those without asthma.
- Subjects :
- Pulmonary and Respiratory Medicine
Adult
Male
Pediatrics
medicine.medical_specialty
Adolescent
Population
Taiwan
Comorbidity
Herpes Zoster
030207 dermatology & venereal diseases
03 medical and health sciences
Young Adult
0302 clinical medicine
Sex Factors
immune system diseases
Adrenal Cortex Hormones
Risk Factors
medicine
Immunology and Allergy
Outpatient clinic
Humans
030212 general & internal medicine
education
Child
Asthma
Proportional Hazards Models
Retrospective Studies
education.field_of_study
business.industry
Proportional hazards model
Incidence
Hazard ratio
Age Factors
Retrospective cohort study
Middle Aged
medicine.disease
respiratory tract diseases
Pediatrics, Perinatology and Child Health
Cohort
Regression Analysis
Female
business
Cohort study
Subjects
Details
- ISSN :
- 15324303
- Volume :
- 54
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- The Journal of asthma : official journal of the Association for the Care of Asthma
- Accession number :
- edsair.doi.dedup.....1d3be3346d9d73ac02e75172888b37d6