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A proof of principle experiment for microbeam radiation therapy at the Munich compact light source
- Source :
- Radiat. Environ. Biophys. 59, 111-120 (2020), Radiation and Environmental Biophysics 59(2020), 111-120
- Publication Year :
- 2019
-
Abstract
- Microbeam radiation therapy (MRT), a preclinical form of spatially fractionated radiotherapy, uses an array of microbeams of hard synchrotron X-ray radiation. Recently, compact synchrotron X-ray sources got more attention as they provide essential prerequisites for the translation of MRT into clinics while overcoming the limited access to synchrotron facilities. At the Munich compact light source (MuCLS), one of these novel compact X-ray facilities, a proof of principle experiment was conducted applying MRT to a xenograft tumor mouse model. First, subcutaneous tumors derived from the established squamous carcinoma cell line FaDu were irradiated at a conventional X-ray tube using broadbeam geometry to determine a suitable dose range for the tumor growth delay. For irradiations at the MuCLS, FaDu tumors were irradiated with broadbeam and microbeam irradiation at integral doses of either 3Gy or 5Gy and tumor growth delay was measured. Microbeams had a width of 50µm and a center-to-center distance of 350µm with peak doses of either 21Gy or 35Gy. A dose rate of up to 5Gy/min was delivered to the tumor. Both doses and modalities delayed the tumor growth compared to a sham-irradiated tumor. The irradiated area and microbeam pattern were verified by staining of the DNA double-strand break marker γH2AX. This study demonstrates for the first time that MRT can be successfully performed in vivo at compact inverse Compton sources.
- Subjects :
- tumor
MRT
compact source
microbeam
Biophysics
Mice, Nude
Radiation
030218 nuclear medicine & medical imaging
law.invention
Histones
03 medical and health sciences
0302 clinical medicine
Light source
Microbeam radiation therapy
growth delay
law
Cell Line, Tumor
Neoplasms
X-rays
Animals
Humans
Irradiation
Growth Delay
Inverse Compton X-ray Sources
Microbeam
Mrt
Tumor
General Environmental Science
Physics
business.industry
X-Rays
equipment and supplies
Synchrotron
Squamous carcinoma
030220 oncology & carcinogenesis
Female
Nuclear medicine
business
Dose rate
Synchrotrons
Subjects
Details
- ISSN :
- 14322099
- Volume :
- 59
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Radiation and environmental biophysics
- Accession number :
- edsair.doi.dedup.....1d33d9499b381be3a10e2b56e12d4d70