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The Survival Advantage of Females at Premenopausal Age Is Race Dependent in Colorectal Cancer
- Source :
- BioMed Research International, BioMed Research International, Vol 2020 (2020)
- Publication Year :
- 2020
- Publisher :
- Hindawi, 2020.
-
Abstract
- Background. A female prognostic advantage in younger individuals has been demonstrated in various cancers. Several large-scale analyses based on different racial backgrounds have reported inconsistent results in colorectal cancer. The aim of the present study was to evaluate the prognostic value of sex and age in patients with colorectal cancer of different ethnic groups. Methods. We identified 71,812 eligible patients from the Surveillance, Epidemiology and End Results database. According to age at diagnosis, the patients were categorized into premenopausal age (≤45 yrs), menopausal age (46–54 yrs), and postmenopausal age (≥55 yrs) subgroups for further analysis. Results. Multivariate analysis identified the female survival advantage to be significant in the premenopausal age subgroup ( P = 0.002 , HR (95% CI): 0.73 (0.60–0.89)), diminished in the menopausal age subgroup ( P = 0.09 ), and absent in the postmenopausal age subgroup ( P = 0.96 ). Furthermore, the female survival advantage at premenopausal age was significant only in white patients ( P = 0.001 , HR (95% CI): 0.68 (0.54–0.87)) and not in either American Indian/Alaska Native or Asian or Pacific Islander patients. There was a trend of better survival of females in black patients ( P = 0.07 ). Conclusions. Sex was a major prognostic factor in colorectal cancer patients, especially premenopausal women, and the difference was also associated with race.
- Subjects :
- 0301 basic medicine
Adult
Male
medicine.medical_specialty
Multivariate analysis
Article Subject
Colorectal cancer
Ethnic group
behavioral disciplines and activities
General Biochemistry, Genetics and Molecular Biology
White People
03 medical and health sciences
Race (biology)
0302 clinical medicine
Internal medicine
Epidemiology
medicine
Ethnicity
Survival advantage
Humans
In patient
General Immunology and Microbiology
business.industry
General Medicine
Middle Aged
medicine.disease
Prognosis
United States
Black or African American
Postmenopause
030104 developmental biology
Premenopause
030220 oncology & carcinogenesis
Multivariate Analysis
Medicine
Pacific islanders
Female
Menopause
business
Colorectal Neoplasms
Research Article
SEER Program
Subjects
Details
- Language :
- English
- ISSN :
- 23146141 and 23146133
- Volume :
- 2020
- Database :
- OpenAIRE
- Journal :
- BioMed Research International
- Accession number :
- edsair.doi.dedup.....1d2062f19c7a8161f526c2ac86f1f6a1