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Fine regulation of Saccharomyces cerevisiae MAPK pathways by post-translational modifications
- Source :
- Yeast. 27:503-511
- Publication Year :
- 2010
- Publisher :
- Wiley, 2010.
-
Abstract
- Saccharomyces cerevisiae has been widely used as a model eukaryotic organism to elucidate the molecular mechanisms that operate upon activation of signalling pathways. For over two decades, many clues to the regulation of mitogen-activated protein kinase (MAPK) pathways have derived from basic research in yeast. Here we review aspects of MAPK pathway fine-tuning, such as the functional implication of feedback loops or regulatory inputs from other pathways, mediated by post-transcriptional modifications on their components. The impact of recent phosphoproteomic approaches in this particular field is also discussed. Copyright © 2010 John Wiley & Sons, Ltd.
- Subjects :
- MAPK/ERK pathway
MAP Kinase Signaling System
Saccharomyces cerevisiae
Bioengineering
Applied Microbiology and Biotechnology
Biochemistry
Fungal Proteins
Ubiquitin
Cell Wall
Gene Expression Regulation, Fungal
Genetics
Phosphorylation
Protein kinase A
biology
Ubiquitination
Phosphoproteomics
biology.organism_classification
Yeast
Cell biology
Posttranslational modification
biology.protein
Mitogen-Activated Protein Kinases
Protein Processing, Post-Translational
Biotechnology
Subjects
Details
- ISSN :
- 0749503X
- Volume :
- 27
- Database :
- OpenAIRE
- Journal :
- Yeast
- Accession number :
- edsair.doi.dedup.....1ce5601ad3e8179ebdb6e76c93881a29