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Brain Atrial Natriuretic Peptide Family Abolishes Cardiovascular Haemodynamic Alterations Caused By Hypertonic Saline In Rats
- Source :
- Clinical and Experimental Pharmacology and Physiology. 26:684-690
- Publication Year :
- 1999
- Publisher :
- Wiley, 1999.
-
Abstract
- SUMMARY 1. Regional haemodynamic alterations caused by hypertonic NaCl solution (Hi-Salt; 10%, 10 μL) injected intracerebroventricularly (i.c.v.) were investigated by using radioactive microspheres in anaesthetized rats. 2. Intracerebroventricular injections of Hi-Salt increased regional vascular resistance of visceral organs, including the kidney, and elevated plasma levels of vasopressin. 3. Intracerebroventricular pretreatment with TCV-11974 (50 μg/10 μL/nat), an angiotensin AT1 receptor antagonist, attenuated the pressor response and vasopressin release to subsequently injected Hi-Salt, but did not affect regional haemodynamic effects of i.c.v. Hi-Salt on vascular resistance. 4. In contrast, i.c.v. pretreatment with atrial natriuretic polypeptide (ANP) or type-C natriuretic polypeptide (CNP) almost completely abolished the haemodynamic changes and vasopressin release caused by i.c.v. Hi-Salt. 5. The present findings indicate that a natriuretic family in the brain may be involved to a great degree in the central regulation of salt-induced hypertension in rats, while brain angiotensin II is likely to participate only in vasopressin release.
- Subjects :
- Male
Vasopressin
medicine.medical_specialty
Physiology
Angiotensin Receptor Antagonists
Atrial natriuretic peptide
Physiology (medical)
Internal medicine
Natriuretic Peptide, Brain
Renin–angiotensin system
medicine
Animals
Rats, Wistar
Saline Solution, Hypertonic
Pharmacology
Receptors, Angiotensin
Angiotensin II receptor type 1
business.industry
Hemodynamics
Natriuretic Peptide, C-Type
Angiotensin II
Rats
Hypertonic saline
medicine.anatomical_structure
Endocrinology
Regional Blood Flow
Vascular resistance
Tonicity
Vascular Resistance
business
Atrial Natriuretic Factor
hormones, hormone substitutes, and hormone antagonists
Subjects
Details
- ISSN :
- 14401681 and 03051870
- Volume :
- 26
- Database :
- OpenAIRE
- Journal :
- Clinical and Experimental Pharmacology and Physiology
- Accession number :
- edsair.doi.dedup.....1cdf474806f4bfdc3b655a0b1161149d