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Dietary lysine deficiency greatly affects muscle and liver protein turnover in growing chickens
- Source :
- British Journal of Nutrition, British Journal of Nutrition, Cambridge University Press (CUP), 1996, 75, pp.853-865
- Publication Year :
- 1996
- Publisher :
- HAL CCSD, 1996.
-
Abstract
- We analysed the respective influences of age and lysine deficiency on skeletal muscle and liver protein turnover. Growing male broilers were fed ad libirum on isoenergetic diets containing 2OO g crude protein/kg which varied in their lysine content (7·7 or 10·1 g/kg). Fractional rates of protein synthesis (FSR) were measured in vivo in the liver and the pectoralis major muscle of 2-, 3- and 4-week-old chickens (flooding dose of l-[143H]phenylalanine). Fractional rates of proteolysis (FBR) were estimated for the same tissues as the difference between synthesis and growth. Over the 2-week period liver FSR and FBR were unchanged, whereas muscle FSR decreased with age. This developmental decline was related to the lower capacity for protein synthesis (Cs) without any modifications of the translational efficiency. Whatever the age, lysine deficiency resulted in significant decreases in body weight, tissue protein content and tissue protein deposition, apparently because of reduced amounts of proteins synthesized. We recorded a difference in the response of the two tissues to lysine deficiency, the pectoralis major being more sensitive than the liver. When comparing birds of the same age, liver FSR and FBR were not modified by the diet, where as muscle FSR, Cs and FBR were higher in chicks fed on a lysinc-deficient diet than in the controls. Conversely, when chicks of similar weights were compared, the main effect of the dietary deficiency was an increase in muscle FBR. The results suggest that lysine deficiency not only delayed chick development so that protein turnover was affected, but also induced greater changes in metabolism. Thus, the principal mechanism whereby muscle mass decreased appeared to be a change in FBR.
- Subjects :
- Male
medicine.medical_specialty
Translational efficiency
Lysine
Medicine (miscellaneous)
Muscle Proteins
Phenylalanine
Biology
03 medical and health sciences
Internal medicine
Protein biosynthesis
medicine
Animals
ComputingMilieux_MISCELLANEOUS
030304 developmental biology
2. Zero hunger
0303 health sciences
Nutrition and Dietetics
Pectoralis major muscle
0402 animal and dairy science
Protein turnover
Skeletal muscle
Proteins
04 agricultural and veterinary sciences
Metabolism
040201 dairy & animal science
Diet
[SDV.AEN] Life Sciences [q-bio]/Food and Nutrition
medicine.anatomical_structure
Endocrinology
Liver
Chickens
[SDV.AEN]Life Sciences [q-bio]/Food and Nutrition
Subjects
Details
- Language :
- English
- ISSN :
- 00071145 and 14752662
- Database :
- OpenAIRE
- Journal :
- British Journal of Nutrition, British Journal of Nutrition, Cambridge University Press (CUP), 1996, 75, pp.853-865
- Accession number :
- edsair.doi.dedup.....1cdce65be648147e0118fe99e83efb1d