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Emodin attenuates A23187-induced mast cell degranulation and tumor necrosis factor-α secretion through protein kinase C and IκB kinase 2 signaling
- Source :
- European journal of pharmacology. 723
- Publication Year :
- 2013
-
Abstract
- Mast cells are known to play a pivotal role in allergic diseases. Cross-linking of the high-affinity IgE receptor (FceRI) is known to be one of the major causes that lead to degranulation and allergic inflammation. An increase in intracellular calcium (Ca(2+)) concentration also triggers degranulation, bypassing receptor activation. Emodin (1,3,8-trihydroxy-6-methylanthraquinone) is known to exhibit a variety of pharmacological activities including anti-allergic effects. However, the detailed molecular mechanisms involved in exhibiting anti-allergic effects by emodin were remained to be clarified. In the present investigation we report the regulatory function of emodin on the allergic signal mediators through Ca(2+) ionophore activation in mast cells. Emodin significantly inhibited A23187-induced tumor necrosis factor-α production and degranulation through the attenuation of protein kinase C, IκB kinase 2, and soluble N-ethylmaleimide-sensitive fusion factor attachment protein receptor complex formation, bypassing FceRI activation. Data from our study indicated that emodin acts by regulating multiple signaling pathways in inhibiting the allergic reactions in mast cells.
- Subjects :
- Receptor complex
Emodin
Cell Degranulation
Bone Marrow Cells
IκB kinase
Biology
Allergic inflammation
chemistry.chemical_compound
Mice
Cell Line, Tumor
Animals
Syk Kinase
Mast Cells
Qc-SNARE Proteins
Protein kinase C
Calcimycin
Cells, Cultured
Protein Kinase C
Pharmacology
Receptors, IgE
Tumor Necrosis Factor-alpha
I-Kappa-B Kinase
Degranulation
Intracellular Signaling Peptides and Proteins
Protein-Tyrosine Kinases
Qb-SNARE Proteins
Cell biology
I-kappa B Kinase
Rats
Mice, Inbred C57BL
chemistry
Calcium
Female
Interleukin-4
SNARE Proteins
Signal Transduction
Subjects
Details
- ISSN :
- 18790712
- Volume :
- 723
- Database :
- OpenAIRE
- Journal :
- European journal of pharmacology
- Accession number :
- edsair.doi.dedup.....1cd80d1d7e4d23f590fcd47f1dd5a0a3