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Changes in Body Composition in Anorexia Nervosa : Predictors of Recovery and Treatment Outcome
- Source :
- Dipòsit Digital de Documents de la UAB, Universitat Autònoma de Barcelona, Repositori Universitat Jaume I, Universitat Jaume I, PLoS ONE, Vol 10, Iss 11, p e0143012 (2015), Recercat. Dipósit de la Recerca de Catalunya, instname, Dipòsit Digital de la UB, Universidad de Barcelona, PLoS ONE
- Publication Year :
- 2015
-
Abstract
- The restoration of body composition (BC) parameters is considered to be one of the most important goals in the treatment of patients with anorexia nervosa (AN). However, little is known about differences between AN diagnostic subtypes [restricting (AN-R) and binge/purging (AN-BP)] and weekly changes in BC during refeeding treatment. Therefore, the main objectives of our study were twofold: 1) to assess the changes in BC throughout nutritional treatment in an AN sample and 2) to analyze predictors of BC changes during treatment, as well as predictors of treatment outcome. The whole sample comprised 261 participants [118 adult females with AN (70 AN-R vs. 48 AN-BP), and 143 healthy controls]. BC was measured weekly during 15 weeks of day-hospital treatment using bioelectrical impedance analysis (BIA). Assessment measures also included the Eating Disorders Inventory-2, as well as a number of other clinical indices. Overall, the results showed that AN-R and AN-BP patients statistically differed in all BC measures at admission. However, no significant time×group interaction was found for almost all BC parameters. Significant time×group interactions were only found for basal metabolic rate (p = .041) and body mass index (BMI) (p = .035). Multiple regression models showed that the best predictors of pre-post changes in BC parameters (namely fat-free mass, muscular mass, total body water and BMI) were the baseline values of BC parameters. Stepwise predictive logistic regressions showed that only BMI and age were significantly associated with outcome, but not with the percentage of body fat. In conclusion, these data suggest that although AN patients tended to restore all BC parameters during nutritional treatment, only AN-BP patients obtained the same fat mass values as healthy controls. Put succinctly, the best predictors of changes in BC were baseline BC values, which did not, however, seem to influence treatment outcome. Instituto de Salud Carlos III [ISCIII] FIS PI11/00210 FIS PI14/00290 Fondos Europeos de Desarrollo Regional (FEDER) funds Servicio Andaluz de Salud (SAS) B-0033-2014 Instituto de Salud Carlos III [Ministerio de de Economia y Competitividad] PSI2011-28349
- Subjects :
- Anorexia Nervosa
Psychiatry and Psychology::Mental Disorders::Eating Disorders::Binge-Eating Disorder [Medical Subject Headings]
Body water
Phenomena and Processes::Physiological Phenomena::Body Constitution::Body Weights and Measures::Body Mass Index [Medical Subject Headings]
lcsh:Medicine
Índice de masa corporal
Anorexia nervosa
Metabolismo basal
Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings]
Fats
Impedancia eléctrica
adolescents
lcsh:Science
Psychiatry and Psychology::Mental Disorders::Eating Disorders::Anorexia Nervosa [Medical Subject Headings]
eating-disorders
Body mass index
Metas
Multidisciplinary
Bulimia nervosa
Femenino
Anorèxia nerviosa
Trastorno por atracón
Modelos logísticos
Anatomy::Tissues::Connective Tissue::Adipose Tissue [Medical Subject Headings]
Humanos
Treatment Outcome
Basal metabolic rate measurement
fat distribution
bioelectrical-impedance
Body Composition
Eating disorders
Obesitat
Female
women
medicine.symptom
Bioelectrical impedance analysis
Research Article
Adult
Tejido adiposo
medicine.medical_specialty
Patient Dropouts
weight-gain
water
Pes corporal
Anatomy::Fluids and Secretions::Body Fluids::Body Water [Medical Subject Headings]
Anorexia nerviosa
Psychiatry and Psychology::Behavior and Behavior Mechanisms::Motivation::Goals [Medical Subject Headings]
Internal medicine
Health Care::Health Care Quality, Access, and Evaluation::Quality of Health Care::Health Care Evaluation Mechanisms::Outcome and Process Assessment (Health Care)::Outcome Assessment (Health Care)::Treatment Outcome [Medical Subject Headings]
medicine
Treatment guidelines
Humans
Obesity
Composición corporal
Health Care::Health Care Quality, Access, and Evaluation::Quality of Health Care::Health Care Evaluation Mechanisms::Statistics as Topic::Models, Statistical::Logistic Models [Medical Subject Headings]
Trastorns de la conducta alimentària
business.industry
lcsh:R
energy-expenditure
duration
Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Techniques, Endocrine::Thyroid Function Tests::Basal Metabolism [Medical Subject Headings]
Phenomena and Processes::Chemical Phenomena::Biochemical Phenomena::Body Composition [Medical Subject Headings]
Body weight
medicine.disease
Agua corporal
Endocrinology
Check Tags::Female [Medical Subject Headings]
Case-Control Studies
Basal metabolic rate
lcsh:Q
Resultado del tratamiento
Phenomena and Processes::Physical Phenomena::Magnetic Phenomena::Electromagnetic Phenomena::Electricity::Electric Conductivity::Electric Impedance [Medical Subject Headings]
business
Weight gain
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Dipòsit Digital de Documents de la UAB, Universitat Autònoma de Barcelona, Repositori Universitat Jaume I, Universitat Jaume I, PLoS ONE, Vol 10, Iss 11, p e0143012 (2015), Recercat. Dipósit de la Recerca de Catalunya, instname, Dipòsit Digital de la UB, Universidad de Barcelona, PLoS ONE
- Accession number :
- edsair.doi.dedup.....1cb991476c99c3bcbb61c619b18b86e7