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Effect of Baseline Characteristics and Tumor Burden on Vaspin Expression and Progressive Disease in Operable Colorectal Cancer
- Source :
- Diagnostics, Vol 10, Iss 801, p 801 (2020), Diagnostics, Volume 10, Issue 10
- Publication Year :
- 2020
- Publisher :
- MDPI AG, 2020.
-
Abstract
- Colorectal cancer is a highly heterogeneous malignancy in the Asian population, and it is considered an important prognostic factor for baseline characteristics, tumor burden, and tumor markers. This study investigated the effect of baseline characteristics and tumor burden on tumor marker expression and progressive disease in colorectal cancer by using partial least squares variance-based path modeling (PLS-PM). PLS-PM can be used to evaluate the complex relationship between prognostic variables and progressive disease status with a small sample of measurements and structural models. A total of 89 tissue samples of colorectal cancer were analyzed. Our results suggested that the expression of visceral adipose tissue-derived serpin (vaspin) is a potential indicator of colorectal cancer progression and may be affected by baseline characteristics such as age, sex, body mass index, and diabetes mellitus. Moreover, according to the characteristics of tumor burden, the expression of vaspin was generally higher in each progressive disease patient. The overall findings suggest that vaspin is a potential indicator of the progressive disease and may be affected by the baseline characteristics of patients.
- Subjects :
- 0301 basic medicine
Oncology
Prognostic variable
medicine.medical_specialty
Colorectal cancer
Clinical Biochemistry
Tumor burden
colorectal cancer
Malignancy
Article
03 medical and health sciences
0302 clinical medicine
Diabetes mellitus
Internal medicine
medicine
Tumor marker
partial least squares path modeling
lcsh:R5-920
business.industry
medicine.disease
030104 developmental biology
030220 oncology & carcinogenesis
vaspin
progressive disease
business
lcsh:Medicine (General)
Body mass index
Progressive disease
tumor burden
Subjects
Details
- Language :
- English
- ISSN :
- 20754418
- Volume :
- 10
- Issue :
- 801
- Database :
- OpenAIRE
- Journal :
- Diagnostics
- Accession number :
- edsair.doi.dedup.....1ca320b6252c3e98ed22b1504d08d386