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Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae
- Source :
- Nature, Nature, Nature Publishing Group, 2005, 438 (7071), pp.1105-1115. ⟨10.1038/nature04341⟩, Nature, 2005, 438 (7071), pp.1105-1115. ⟨10.1038/nature04341⟩
- Publication Year :
- 2005
- Publisher :
- Springer Science and Business Media LLC, 2005.
-
Abstract
- International audience; The aspergilli comprise a diverse group of filamentous fungi spanning over 200 million years of evolution. Here we report the genome sequence of the model organism Aspergillus nidulans, and a comparative study with Aspergillus fumigatus, a serious human pathogen, and Aspergillus oryzae, used in the production of sake, miso and soy sauce. Our analysis of genome structure provided a quantitative evaluation of forces driving long-term eukaryotic genome evolution. It also led to an experimentally validated model of mating-type locus evolution, suggesting the potential for sexual reproduction in A. fumigatus and A. oryzae. Our analysis of sequence conservation revealed over 5,000 non-coding regions actively conserved across all three species. Within these regions, we identified potential functional elements including a previously uncharacterized TPP riboswitch and motifs suggesting regulation in filamentous fungi by Puf family genes. We further obtained comparative and experimental evidence indicating widespread translational regulation by upstream open reading frames. These results enhance our understanding of these widely studied fungi as well as provide new insight into eukaryotic genome evolution and gene regulation.
- Subjects :
- Proteome
Molecular Sequence Data
Genomics
SEQUENCE DATA
[SDV.BC]Life Sciences [q-bio]/Cellular Biology
Regulatory Sequences, Nucleic Acid
Synteny
Genome
Aspergillus fumigatus
Evolution, Molecular
Open Reading Frames
03 medical and health sciences
GENE REGULATION
Aspergillus oryzae
Aspergillus nidulans
Consensus Sequence
Humans
ASPERGILLUS FUMIGATUS
Gene
Conserved Sequence
Phylogeny
030304 developmental biology
Genetics
Whole genome sequencing
SEQUENCE CONSERVATION
GENOME EVOLUTION
0303 health sciences
Multidisciplinary
Base Sequence
biology
GENOMIC
030306 microbiology
Fungal genetics
Sequence Analysis, DNA
15. Life on land
Genes, Mating Type, Fungal
biology.organism_classification
ASPERGILLUS ORYZAE
ASPERGILLUS NIDULANS
Genome, Fungal
Subjects
Details
- ISSN :
- 14764687, 00280836, and 14764679
- Volume :
- 438
- Database :
- OpenAIRE
- Journal :
- Nature
- Accession number :
- edsair.doi.dedup.....1c9c31c34471cf5b57d5e81cf480f8b7