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Farnesal-loaded pH-sensitive polymeric micelles provided effective prevention and treatment on dental caries
- Source :
- Journal of Nanobiotechnology, Journal of Nanobiotechnology, Vol 18, Iss 1, Pp 1-16 (2020)
- Publication Year :
- 2020
-
Abstract
- Background Farnesol is a sesquiterpene from propolis and citrus fruit that shows promising anti-bacterial activity for caries treatment and prevention, but its hydrophobicity limits the clinical application. We aimed to develop the novel polymeric micelles (PMs) containing a kind of derivative of farnesol and a ligand of pyrophosphate (PPi) that mediated PMs to adhere tightly with the tooth enamel. Results Farnesal (Far) was derived from farnesol and successfully linked to PEG via an acid-labile hydrazone bond to form PEG-hyd-Far, which was then conjugated to PPi and loaded into PMs to form the aimed novel drug delivery system, PPi-Far-PMs. The in vitro test about the binding of PPi-Far-PMs to hydroxyapatite showed that PPi-Far-PMs could bind rapidly to hydroxyapatite and quickly release Far under the acidic conditions. Results from the mechanical testing and the micro-computed tomography indicated that PPi-Far-PMs could restore the microarchitecture of teeth with caries. Moreover, PPi-Far-PMs diminished the incidence and severity of smooth and sulcal surface caries in rats that were infected with Streptococcus mutans while being fed with a high-sucrose diet. The anti-caries efficacy of free Far can be improved significantly by PPi-Far-PMs through the effective binding of it with tooth enamel via PPi. Conclusions This novel drug-delivery system may be useful for the treatment and prevention of dental caries as well as the targeting therapy of anti-bacterial drugs in the oral disease.
- Subjects :
- Pharmaceutical Science
Medicine (miscellaneous)
02 engineering and technology
Pharmacology
Applied Microbiology and Biotechnology
Pyrophosphate
Polyethylene Glycols
Streptococcus mutans
chemistry.chemical_compound
Micelles
0303 health sciences
Drug Carriers
biology
021001 nanoscience & nanotechnology
Ligand (biochemistry)
Farnesol
Cariostatic Agents
Diphosphates
medicine.anatomical_structure
lcsh:R855-855.5
Drug delivery
Molecular Medicine
Polymeric micelles
0210 nano-technology
Hydrophobic and Hydrophilic Interactions
lcsh:Medical technology
lcsh:Biotechnology
Biomedical Engineering
Bioengineering
Dental Caries
Sesquiterpene
Hydroxyapatite
03 medical and health sciences
lcsh:TP248.13-248.65
PEG ratio
medicine
Animals
030306 microbiology
Research
pH-sensitive
Tooth enamel
biology.organism_classification
Molar
Rats
stomatognathic diseases
Durapatite
chemistry
Farnesal
Subjects
Details
- ISSN :
- 14773155
- Volume :
- 18
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Journal of nanobiotechnology
- Accession number :
- edsair.doi.dedup.....1c8afe961c4954953945b6848bd48165