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Metabolomes of sperm and seminal plasma associated with bull fertility
- Source :
- Animal reproduction science. 220
- Publication Year :
- 2020
-
Abstract
- Bull fertility is crucial for efficient, profitable, and sustainable agriculture of cattle. Despite the fact that the uses of sperm from low fertility bulls cause millions of dollars economic losses, conventional methods available to accurately predict bull fertility are still of limited use. Although breeding bulls produce billions of sperm mostly with normal motility and morphology, some bulls are afflicted with poor fertility due to molecular or cellular defects in the sperm. Sperm functional genome including transcriptome, proteome, and metabolome influence bull fertility. Through high throughput screening methods of metabolomics, specific small molecules have been described both for seminal plasma and sperm. Compared to sperm, seminal plasma contains much higher numbers and levels of metabolites. Although the identities and functions of many of these metabolites are known, such knowledge is still yet to be generated for a greater number of metabolites of sperm and seminal plasma. Once validated as fertility markers, sperm, and seminal plasma metabolites can be used to evaluate semen quality and predict bull fertility, and/or used in assisted reproductive technologies. This review describes the possibility to use small molecules (in the review called metabolites) as fertility predictors.
- Subjects :
- Male
endocrine system
animal diseases
media_common.quotation_subject
Fertility
Reproductive technology
Biology
Transcriptome
Andrology
03 medical and health sciences
Semen quality
0302 clinical medicine
Endocrinology
Metabolomics
Food Animals
Semen
Metabolome
Animals
reproductive and urinary physiology
media_common
High-Throughput Screening Methods
030219 obstetrics & reproductive medicine
urogenital system
0402 animal and dairy science
04 agricultural and veterinary sciences
General Medicine
040201 dairy & animal science
Sperm
Spermatozoa
Animal Science and Zoology
Cattle
Subjects
Details
- ISSN :
- 18732232
- Volume :
- 220
- Database :
- OpenAIRE
- Journal :
- Animal reproduction science
- Accession number :
- edsair.doi.dedup.....1c74acf383e2c72da9d961070a244bf6