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Indirect Protection of Adults From Rotavirus by Pediatric Rotavirus Vaccination
- Source :
- Clinical Infectious Diseases. 56:755-760
- Publication Year :
- 2013
- Publisher :
- Oxford University Press (OUP), 2013.
-
Abstract
- Background Pediatric vaccination has resulted in declines in disease in unvaccinated individuals through decreasing pathogen circulation in the community. About 2 years after implementation of pediatric rotavirus vaccination in the United States, dramatic declines in rotavirus disease were observed in both vaccinated and unvaccinated children. Whether this protection extends to adults is unknown. Methods The prevalence of rotavirus, as determined by Rotaclone enzyme immunoassay, in adults who had stools submitted for bacterial stool culture (BSC) between February to May to Northwestern Memorial Hospital, Chicago, was compared between the prepediatric impact era (2006-2007) and the pediatric impact era (2008-2010). Isolates were genotyped and clinical characteristics of those with rotavirus were compared. Results Of the 5788 BSC sent, 4725 met inclusion criteria and 3530 of these (74.7%) were saved for rotavirus testing. The prevalence of rotavirus among adults who had stool sent for BSC declined from 4.35% in 2006-2007 to 2.24% in 2008-2010 (a relative decline of 48.4%; P = .0007). The decline in the prevalence of rotavirus was of similar significant magnitude in both outpatients and inpatients. Marked year-to-year variability was observed in circulating rotavirus genotypes, with strain G2P[4] accounting for 24%; G1P[8], 22%; G3P[8], 11%; and G12P[6], 10% overall. About 30% of adults from whom rotavirus was isolated were immunocompromised and this remained constant. Conclusions Pediatric rotavirus vaccination correlated with a relative decline of almost 50% in rotavirus identified from adult BSC during the peak rotavirus season, suggesting that pediatric rotavirus vaccination protects adults from rotavirus.
- Subjects :
- Adult
Male
Rotavirus
Microbiology (medical)
Pediatrics
medicine.medical_specialty
Adolescent
Genotype
viruses
Enzyme-Linked Immunosorbent Assay
Rotavirus vaccination
medicine.disease_cause
Rotavirus disease
Rotavirus Infections
Feces
Young Adult
fluids and secretions
Viral genetics
Prevalence
medicine
Stool culture
Humans
Young adult
Chicago
business.industry
Vaccination
Rotavirus Vaccines
virus diseases
Middle Aged
Virology
Infectious Diseases
RNA, Viral
Female
business
Subjects
Details
- ISSN :
- 15376591 and 10584838
- Volume :
- 56
- Database :
- OpenAIRE
- Journal :
- Clinical Infectious Diseases
- Accession number :
- edsair.doi.dedup.....1c5e1d22e4969961501cafb6bf545af5