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Lopinavir/ritonavir Reduces Bupropion Plasma Concentrations in Healthy Subjects
- Source :
- Clinical Pharmacology & Therapeutics. 81:69-75
- Publication Year :
- 2007
- Publisher :
- Springer Science and Business Media LLC, 2007.
-
Abstract
- Limited data are available about the effect of steady-state lopinavir and ritonavir (LPV/r) on bupropion pharmacokinetics. As patients may benefit by using these two agents in combination, this study determined the extent and direction of this drug-drug interaction. Twelve healthy volunteers received a single 100 mg dose of sustained-release bupropion before and after 2 weeks of treatment with LPV/r 400 mg/100 mg twice daily. Pharmacokinetics profiles were determined on days 1 and 30 for bupropion and hydroxybupropion and days 29 and 30 for LPV/r. LPV/r administration significantly decreased bupropion maximum plasma concentration (C(max)) by 57% (90% confidence interval (CI), 38-76%; P
- Subjects :
- Adult
Male
Metabolic Clearance Rate
Lopinavir/ritonavir
Pyrimidinones
Pharmacology
Lopinavir
Pharmacokinetics
mental disorders
medicine
Humans
Pharmacology (medical)
Bupropion
Active metabolite
Ritonavir
business.industry
Area under the curve
Hydroxybupropion
HIV Protease Inhibitors
Drug Combinations
Area Under Curve
Antidepressive Agents, Second-Generation
Female
business
Drug Antagonism
Half-Life
medicine.drug
Subjects
Details
- ISSN :
- 15326535 and 00099236
- Volume :
- 81
- Database :
- OpenAIRE
- Journal :
- Clinical Pharmacology & Therapeutics
- Accession number :
- edsair.doi.dedup.....1c5503c0ba16e7b6bf81b4d42898f789