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Temporal changes in biomarkers and their relationships to reperfusion and to clinical outcomes among patients with ST segment elevation myocardial infarction
- Source :
- Journal of thrombosis and thrombolysis. 42(3)
- Publication Year :
- 2016
-
Abstract
- Coronary plaque rupture mediating acute ST segment elevation myocardial infarction (STEMI) is associated with a systemic inflammatory response. Whether early temporal changes in inflammatory biomarkers are associated with angiographic and electrocardiographic markers of reperfusion and subsequent clinical outcomes is unclear. In the APEX-AMI biomarker substudy, 376 patients with STEMI had inflammatory biomarkers measured at the time of hospital presentation and 24 h later. The primary outcome was the 90-day composite of death, shock, or heart failure. Secondary reperfusion outcomes were (1) worst least residual ST segment elevation (ST-E
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
Time Factors
medicine.drug_class
Shock, Cardiogenic
Myocardial Reperfusion
030204 cardiovascular system & hematology
Coronary Angiography
Cohort Studies
03 medical and health sciences
Electrocardiography
0302 clinical medicine
Internal medicine
Natriuretic Peptide, Brain
medicine
Natriuretic peptide
ST segment
Humans
Myocardial infarction
Heart Failure
Inflammation
medicine.diagnostic_test
business.industry
Interleukin-6
Tumor Necrosis Factor-alpha
Hazard ratio
Hematology
medicine.disease
Peptide Fragments
Interleukin-10
030104 developmental biology
Treatment Outcome
Heart failure
Shock (circulatory)
Cardiology
ST Elevation Myocardial Infarction
medicine.symptom
Cardiology and Cardiovascular Medicine
business
TIMI
Biomarkers
Subjects
Details
- ISSN :
- 1573742X
- Volume :
- 42
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Journal of thrombosis and thrombolysis
- Accession number :
- edsair.doi.dedup.....1c3f52ff97b73b587192115f980a73c3