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Reviewing Chandipura: A Vesiculovirus in Human Epidemics
- Source :
- Bioscience Reports
- Publication Year :
- 2007
- Publisher :
- Springer US, 2007.
-
Abstract
- Chandipura virus, a member of the rhabdoviridae family and vesiculovirus genera, has recently emerged as human pathogen that is associated with a number of outbreaks in different parts of India. Although, the virus closely resembles with the prototype vesiculovirus, Vesicular Stomatitis Virus, it could be readily distinguished by its ability to infect humans. Studies on Chandipura virus while shed light into distinct stages of viral infection; it may also allow us to identify potential drug targets for antiviral therapy. In this review, we have summarized our current understanding of Chandipura virus life cycle at the molecular detail with particular interest in viral RNA metabolisms, namely transcription, replication and packaging of viral RNA into nucleocapsid structure. Contemporary research on otherwise extensively studied family member Vesicular Stomatitis Virus has also been addressed to present a more comprehensive picture of vesiculovirus life cycle. Finally, we reveal examples of protein economy in Chandipura virus life-cycle whereby each viral protein has evolved complexity to perform multiple tasks.
- Subjects :
- Gene Expression Regulation, Viral
Transcription, Genetic
Viral protein
viruses
Encapsidation
Biophysics
Replication
India
Human pathogen
medicine.disease_cause
Virus Replication
Biochemistry
Communicable Diseases, Emerging
Virus
Chandipura virus
Viral Matrix Proteins
Viral Envelope Proteins
Transcription (biology)
Rhabdoviridae Infections
medicine
Humans
Nucleocapsid
Molecular Biology
Genetics
Nucleocapsid protein
Viral Structural Proteins
Original Paper
biology
Cell Biology
Economy
Vesiculovirus
Rhabdoviridae
Nucleocapsid Proteins
biology.organism_classification
Phosphoproteins
Virology
Leader RNA
Ribonucleoproteins
Vesicular stomatitis virus
Phosphoprotein
RNA, Viral
Transcription
Multi-functional
Molecular Chaperones
Subjects
Details
- Language :
- English
- ISSN :
- 15734935 and 01448463
- Volume :
- 27
- Issue :
- 4-5
- Database :
- OpenAIRE
- Journal :
- Bioscience Reports
- Accession number :
- edsair.doi.dedup.....1c3b20bd08d526b8619b17726de45515