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Expression of cornulin in oral premalignant lesions
- Source :
- Oral surgery, oral medicine, oral pathology and oral radiology. 127(6)
- Publication Year :
- 2018
-
Abstract
- Objective The aim of this study was to evaluate expression of cornulin in oral mucosa as an adjunct to histopathologic grading of oral epithelial dysplasia (OED). Study Design Biomarker expression was assessed in normal oral mucosa, low-grade OED (LD), high-grade OED (HD), and oral squamous cell carcinoma (OSCC) by using immunohistochemistry. Photomicrographs were evaluated with Aperio Imagescope using a positive-pixel-counting algorithm. A histo-score (H-score) was calculated on the basis of staining intensity and the percentage of positive cells (%-staining). Intrarater reliability for H-score and %-staining was determined by calculating interclass correlation coefficients. Mean differences in H-scores and %-percent staining values were each analyzed by using an analysis of variance and Tukey's post hoc procedure. Results Cornulin expression progressively diminished with increasing grades of dysplasia and OSCC. Interclass correlation coefficients for H-score and %-staining were each greater than 0.99. Except for OSCC versus HD, all other pairwise comparisons were statistically significant (P Conclusions Cornulin expression helped differentiate between low-grade and high-grade oral epithelial dysplasia, making it a potential adjunct for grading oral OEDs and a potential biomarker for risk of lesion progression. Longitudinal studies evaluating risk stratification based on cornulin expression may be warranted.
- Subjects :
- Epithelial dysplasia
medicine.medical_specialty
Interclass correlation
Gastroenterology
Pathology and Forensic Medicine
03 medical and health sciences
0302 clinical medicine
Internal medicine
medicine
Carcinoma
Biomarkers, Tumor
Humans
Radiology, Nuclear Medicine and imaging
Dentistry (miscellaneous)
Oral mucosa
Grading (tumors)
Mouth neoplasm
business.industry
Mouth Mucosa
Reproducibility of Results
030206 dentistry
medicine.disease
stomatognathic diseases
medicine.anatomical_structure
Dysplasia
030220 oncology & carcinogenesis
Carcinoma, Squamous Cell
Biomarker (medicine)
Surgery
Mouth Neoplasms
Oral Surgery
business
Precancerous Conditions
Subjects
Details
- ISSN :
- 22124411
- Volume :
- 127
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Oral surgery, oral medicine, oral pathology and oral radiology
- Accession number :
- edsair.doi.dedup.....1c363e23ee77759db9339fa438b2f51f