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Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits
- Source :
- Nature Genetics, Nature Genetics, 50(10), 1412-+. Nature Publishing Group, Nature genetics (Online) 50 (2018): 1412–1425. doi:10.1038/s41588-018-0205-x, info:cnr-pdr/source/autori:Evangelou E.; Warren H.R.; Mosen-Ansorena D.; Mifsud B.; Pazoki R.; Gao H.; Ntritsos G.; Dimou N.; Cabrera C.P.; Karaman I.; Ng F.L.; Evangelou M.; Witkowska K.; Tzanis E.; Hellwege J.N.; Giri A.; Velez Edwards D.R.; Sun Y.V.; Cho K.; Gaziano J.M.; Wilson P.W.F.; Tsao P.S.; Kovesdy C.P.; Esko T.; Magi R.; Milani L.; Almgren P.; Boutin T.; Debette S.; Ding J.; Giulianini F.; Holliday E.G.; Jackson A.U.; Li-Gao R.; Lin W.-Y.; Luan J.; Mangino M.; Oldmeadow C.; Prins B.P.; Qian Y.; Sargurupremraj M.; Shah N.; Surendran P.; Theriault S.; Verweij N.; Willems S.M.; Zhao J.-H.; Amouyel P.; Connell J.; de Mutsert R.; Doney A.S.F.; Farrall M.; Menni C.; Morris A.D.; Noordam R.; Pare G.; Poulter N.R.; Shields D.C.; Stanton A.; Thom S.; Abecasis G.; Amin N.; Arking D.E.; Ayers K.L.; Barbieri C.M.; Batini C.; Bis J.C.; Blake T.; Bochud M.; Boehnke M.; Boerwinkle E.; Boomsma D.I.; Bottinger E.P.; Braund P.S.; Brumat M.; Campbell A.; Campbell H.; Chakravarti A.; Chambers J.C.; Chauhan G.; Ciullo M.; Cocca M.; Collins F.; Cordell H.J.; Davies G.; Borst M.H.; Geus E.J.; Deary I.J.; Deelen J.; Del Greco M F.; Demirkale C.Y.; Dorr M.; Ehret G.B.; Elosua R.; Enroth S.; Erzurumluoglu A.M.; Ferreira T.; Franberg M.; Franco O.H.; Gandin I.; Gasparini P.; Giedraitis V.; Gieger C.; Girotto G.; Goel A.; Gow A.J.; Gudnason V.; Guo X.; Gyllensten U.; Hamsten A.; Harris T.B.; Harris S.E.; Hartman C.A.; Havulinna A.S.; Hicks A.A.; Hofer E.; Hofman A.; Hottenga J.-J.; Huffman J.E.; Hwang S.-J.; Ingelsson E.; James A.; Jansen R.; Jarvelin M.-R.; Joehanes R.; Johansson A.; Johnson A.D.; Joshi P.K.; Jousilahti P.; Jukema J.W.; Jula A.; Kahonen M.; Kathiresan S.; Keavney B.D.; Khaw K.-T.; Knekt P.; Knight J.; Kolcic I.; Kooner J.S.; Koskinen S.; Kristiansson K.; Kutalik Z.; Laan M.; Larson M.; Launer L.J.; Lehne B.; Lehtimaki T.; Liewald D.C.M.; Lin L.; Lind L.; Lindgren C.M.; Liu Y.M.; Loos R.J.F.; Lopez L.M.; Lu Y.; Lyytikainen L.-P.; Mahajan A.; Mamasoula C.; Marrugat J.; Marten J.; Milaneschi Y.; Morgan A.; Morris A.P.; Morrison A.C.; Munson P.J.; Nalls M.A.; Nandakumar P.; Nelson C.P.; Niiranen T.; Nolte I.M.; Nutile T.; Oldehinkel A.J.; Oostra B.A.; O'Reilly P.F.; Org E.; Padmanabhan S.; Palmas W.; Palotie A.; Pattie A.; Penninx B.W.J.H.; Perola M.; Peters A.; Polasek O.; Pramstaller P.P.; Nguyen Q.T.; Raitakari O.T.; Ren M.; Rettig R.; Rice K.; Ridker P.M.; Ried J.S.; Riese H.; Ripatti S.; Robino A.; Rose L.M.; Rotter J.I.; Rudan I.; Ruggiero D.; Saba Y.; Sala C.F.; Salomaa V.; Samani N.J.; Sarin A.-P.; Schmidt R.; Schmidt H.; Shrine N.; Siscovick D.; Smith A.V.; Snieder H.; Sober S.; Sorice R.; Starr J.M.; Stott D.J.; Strachan D.P.; Strawbridge R.J.; Sundstrom J.; Swertz M.A.; Taylor K.D.; Teumer A.; Tobin M.D.; Tomaszewski M.; Toniolo D.; Traglia M.; Trompet S.; Tuomilehto J.; Tzourio C.; Uitterlinden A.G.; Vaez A.; van der Most P.J.; van Duijn C.M.; Vergnaud A.-C.; Verwoert G.C.; Vitart V.; Volker U.; Vollenweider P.; Vuckovic D.; Watkins H.; Wild S.H.; Willemsen G.; Wilson J.F.; Wright A.F.; Yao J.; Zemunik T.; Zhang W.; Attia J.R.; Butterworth A.S.; Chasman D.I.; Conen D.; Cucca F.; Danesh J.; Hayward C.; Howson J.M.M.; Laakso M.; Lakatta E.G.; Langenberg C.; Melander O.; Mook-Kanamori D.O.; Palmer C.N.A.; Risch L.; Scott R.A.; Scott R.J.; Sever P.; Spector T.D.; van der Harst P.; Wareham N.J.; Zeggini E.; Levy D.; Munroe P.B.; Newton-Cheh C.; Brown M.J.; Metspalu A.; Hung A.M.; O'Donnell C.J.; Edwards T.L.; Psaty B.M.; Tzoulaki I.; Barnes M.R.; Wain L.V.; Elliott P.; Caulfield M.J./titolo:Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits/doi:10.1038%2Fs41588-018-0205-x/rivista:Nature genetics (Online)/anno:2018/pagina_da:1412/pagina_a:1425/intervallo_pagine:1412–1425/volume:50, Nature Genetics, 50(10), 1412-1431. Nature Publishing Group, Nature Genetics, Vol. 50, No 10 (2018) pp. 1412-1425, Keavney, B, Tomaszewski, M, Morris, A & et al 2018, ' Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits ', Nature Genetics, vol. 50, no. 10, pp. 1412-1425 . https://doi.org/10.1038/s41588-018-0205-x, Boomsma, D I, de Geus, E J C, Hottenga, J J, Willemsen, G & the Million Veteran Program 2018, ' Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits ', Nature Genetics, vol. 50, no. 10, pp. 1412-1431 . https://doi.org/10.1038/s41588-018-0205-x, the Million Veteran Program 2018, ' Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits ', Nature Genetics, vol. 50, no. 10, pp. 1412-1425 . https://doi.org/10.1038/s41588-018-0205-x, Nature Genetics, Nature Publishing Group, 2018, 50 (10), pp.1412-1425. ⟨10.1038/s41588-018-0205-x⟩, Nature Genetics, 50(10), 1412, Nature Genetics, 50(10), 1412-1425. Nature Publishing Group, Evangelou, E, Warren, H R, Mosen-Ansorena, D, Mifsud, B, Pazoki, R, Gao, H, Ntritsos, G, Dimou, N, Cabrera-Cardenas, C, Karaman, I, Liang Ng, F, Evangelou, M, Witkowska, K, Tzanis, E, Hellwege, J N, Giri, A, Velez Edwards, D R, Sun, Y V, Cho, K, Gaziano, J M, Wilson, P W F, Tsao, P S, Kovesdy, C P, Esko, T, Mägi, R, Milani, L, Almgren, P, Boutin, T, Debette, S, Ding, J, Giulianini, F, Holliday, E G, Jackson, A U, Li-Gao, R, Lin, W-Y, Luan, J, Mangino, M, Oldmeadow, C, Prins, B P, Qian, Y, Sargurupremraj, M, Shah, N, Surendran, P, Theriault, S, Verweij, N, Willems, S M, Zhao, J H, Amouyel, P, Connell, J M C, de Mutsert, R, Doney, A S F, Farrall, M, Menni, C, Morris, A, Noordam, R, Paré, G, Poulter, N R, Shields, D C, Stanton, A V, Thom, S, Abecasis, G R, Amin, N, Arking, D E, Ayers, K L, Barbieri, C M, Batini, C, Bis, J C, Blake, T, Bochud, M, Boehnke, M, Boerwinkle, E, Boomsma, D I, Bottinger, E P, Braund, P S, Brumat, M, Campbell, A, Campbell, H, Chakravarti, A, Chambers, J C, Chauhan, G, Ciullo, M, Cocca, M, Collins, F S, Cordell, H J, Davies, G, de Borst, M H, Geus, E J C, Deary, I, Deelen, J, Del Greco, F M, Demirkale, Y, Dörr, M, Ehret, G B, Elosua, R, Enroth, S, Erzurumluoglu, A M, Ferreira, T, Frånberg, M, Franco, O H, Gandin, I, Gasparini, P, Giedraitis, V, Gieger, C, Girotto, G, Goel, A, Gow, A J, Gudnason, V, Guo, X, Gyllensten, U, Hamsten, A, Harris, T B, Harris, S, Hartman, C A, Havulinna, A S, Hicks, A A, Hofer, E, Hofman, A, Hottenga, J-J, Huffman, J E, Hwang, S-J, Ingelsson, E, James, A L, Jansen, R, Jarvelin, M-R, Joehanes, R, Johansson, Å, Johnson, A D, Joshi, P, Jousilahti, P, Jukema, J W, Jula, A, Kähönen, M, Kathiresan, S, Keavney, B D, Khaw, K T, Knekt, P, Knight, J, Kolcic, I, Kooner, J S, Koskinen, S, Kristiansson, K, Kutalik, Z, Laan, M, Larson, M, Launer, L J, Lehne, B, Lehtimäki, T, Liewald, D, Lin, L, Lind, L, Lindgren, C M, Liu, Y, Loos, R J, Lopez, L, Lu, Y, Lyytikäinen, L-P, Mahajan, A, Mamasoula, C, Marrugat, J, Marten, J, Milaneschi, Y, Morgan, A, Morris, A P, Morrison, A C, Munson, P J, Nalls, M A, Nandakumar, P, Nelson, C P, Niiranen, T, Nolte, I M, Nutile, T, Oldehinkel, A J, Oostra, B A, O'Reilly, P F, Org, E, Padmanabhan, S, Palmas, W, Palotie, A, Pattie, A, Penninx, B W J H, Perola, M, Peters, A, Polasek, O, Pramstaller, P P, Tri Nguyen, Q, Raitakari, O T, Ren, M, Rettig, R, Rice, K M, Ridker, P M, Ried, J S, Riese, H, Ripatti, S, Robino, A, Rose, L M, Rotter, J I, Rudan, I, Ruggiero, D, Saba, Y, Sala, C F, Salomaa, V, Samani, N J, Sarin, A-P, Schmidt, R, Schmidt, H, Shrine, N R G, Siscovick, D S, Smith, A V, Snieder, H, Sõber, S, Sorice, R, Starr, J, Stott, D J, Strachan, D P, Strawbridge, R J, Sundstrom, J, Swertz, M A, Taylor, K D, Teumer, A, Tobin, M D, Tomaszewski, M, Toniolo, D, Traglia, M, Trompet, S, Tuomilehto, J, Tzourio, C, Uitterlinden, A G, Vaez, A, van der Most, P J, van Duijn, C M, Vergnaud, A-C, Verwoert, G C, Vitart, V, Völker, U, Vollenweider, P, Vuckovic, D, Watkins, H, Wild, S, Willemsen, G, Wilson, J, Wrightl, A F, Yao, J, Zemunik, T, Zhang, W, Attia, J, Butterworth, A S, Chasman, D I, Conen, D, Cucca, F, Danesh, J, Hayward, C, Howson, J MM, Laakso, M, Lakatta, E G, Langenberg, C, Melander, O, Mook-Kanamori, D O, Palmer, C N A, Risch, L, Scott, R A, Scott, R J, Sever, P, Spector, T D, van der Harst, P, Wareham, N J, Zeggini, E, Levy, D, Munroe, P B, Newton-Cheh, C, Brown, M J, Metspalu, A, Hung, A M, O'Donnell, C J, Edwards, T L, Psaty, B M, Tzoulaki, I, Barnes, M R, Wain, L V, Elliott, P & Caulfield, M J 2018, ' Genetic analysis of over one million people identifies 535 new loci associated with blood pressure traits ', Nature Genetics, vol. 50, pp. 1412–1425 . https://doi.org/10.1038/s41588-018-0205-x, Nat Genet
- Publication Year :
- 2018
-
Abstract
- High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future. NMRC (Natl Medical Research Council, S’pore) MOH (Min. of Health, S’pore)
- Subjects :
- Male
0301 basic medicine
Netherlands Twin Register (NTR)
Population/methods
Genome Informatics
Blood Pressure
Genome-wide association study
GENOME-WIDE ASSOCIATION
CARDIOVASCULAR-DISEASE RISK
UK BIOBANK
HYPERTENSION
VARIANTS
METAANALYSIS
COMMON
HEALTH
RARE
HYPERALDOSTERONISM
Disease
Bioinformatics
Cardiovascular Diseases/epidemiology/genetics
Risk Factors
80 and over
GWAS
Cells, Cultured
11 Medical and Health Sciences
ddc:616
Genetics & Heredity
Aged, 80 and over
Cultured
medicine.diagnostic_test
CARDIOVASCULAR RISK
Genetic analysis
Million Veteran Program
Genetics, Population/methods
Single Nucleotide
Middle Aged
PREVALENCE
3. Good health
Pulse pressure
VINTAGE
Cardiovascular Diseases
Blood pressure
Medical genetics
Female
Medical Genetics
Life Sciences & Biomedicine
Genetic Testing/methods
Adult
medicine.medical_specialty
Blood Pressure/genetics
Cells
Quantitative Trait Loci
Biology
Polymorphism, Single Nucleotide
Article
03 medical and health sciences
SDG 3 - Good Health and Well-being
Human Umbilical Vein Endothelial Cells
Genetics
medicine
Humans
Medicine [Science]
Genetic Predisposition to Disease
Genetic Testing
Polymorphism
HEALTHY
Life Style
Medicinsk genetik
Aged
Genetic testing
Genetic association
Science & Technology
Cardiovascular Diseases/epidemiology
06 Biological Sciences
Genetic architecture
Genetics, Population
030104 developmental biology
Genetic Loci
[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
3111 Biomedicine
Hypertension/genetics
Genome-Wide Association Study
Developmental Biology
Subjects
Details
- Language :
- English
- ISSN :
- 15461718 and 10614036
- Database :
- OpenAIRE
- Journal :
- Nature Genetics, Nature Genetics, 50(10), 1412-+. Nature Publishing Group, Nature genetics (Online) 50 (2018): 1412–1425. doi:10.1038/s41588-018-0205-x, info:cnr-pdr/source/autori:Evangelou E.; Warren H.R.; Mosen-Ansorena D.; Mifsud B.; Pazoki R.; Gao H.; Ntritsos G.; Dimou N.; Cabrera C.P.; Karaman I.; Ng F.L.; Evangelou M.; Witkowska K.; Tzanis E.; Hellwege J.N.; Giri A.; Velez Edwards D.R.; Sun Y.V.; Cho K.; Gaziano J.M.; Wilson P.W.F.; Tsao P.S.; Kovesdy C.P.; Esko T.; Magi R.; Milani L.; Almgren P.; Boutin T.; Debette S.; Ding J.; Giulianini F.; Holliday E.G.; Jackson A.U.; Li-Gao R.; Lin W.-Y.; Luan J.; Mangino M.; Oldmeadow C.; Prins B.P.; Qian Y.; Sargurupremraj M.; Shah N.; Surendran P.; Theriault S.; Verweij N.; Willems S.M.; Zhao J.-H.; Amouyel P.; Connell J.; de Mutsert R.; Doney A.S.F.; Farrall M.; Menni C.; Morris A.D.; Noordam R.; Pare G.; Poulter N.R.; Shields D.C.; Stanton A.; Thom S.; Abecasis G.; Amin N.; Arking D.E.; Ayers K.L.; Barbieri C.M.; Batini C.; Bis J.C.; Blake T.; Bochud M.; Boehnke M.; Boerwinkle E.; Boomsma D.I.; Bottinger E.P.; Braund P.S.; Brumat M.; Campbell A.; Campbell H.; Chakravarti A.; Chambers J.C.; Chauhan G.; Ciullo M.; Cocca M.; Collins F.; Cordell H.J.; Davies G.; Borst M.H.; Geus E.J.; Deary I.J.; Deelen J.; Del Greco M F.; Demirkale C.Y.; Dorr M.; Ehret G.B.; Elosua R.; Enroth S.; Erzurumluoglu A.M.; Ferreira T.; Franberg M.; Franco O.H.; Gandin I.; Gasparini P.; Giedraitis V.; Gieger C.; Girotto G.; Goel A.; Gow A.J.; Gudnason V.; Guo X.; Gyllensten U.; Hamsten A.; Harris T.B.; Harris S.E.; Hartman C.A.; Havulinna A.S.; Hicks A.A.; Hofer E.; Hofman A.; Hottenga J.-J.; Huffman J.E.; Hwang S.-J.; Ingelsson E.; James A.; Jansen R.; Jarvelin M.-R.; Joehanes R.; Johansson A.; Johnson A.D.; Joshi P.K.; Jousilahti P.; Jukema J.W.; Jula A.; Kahonen M.; Kathiresan S.; Keavney B.D.; Khaw K.-T.; Knekt P.; Knight J.; Kolcic I.; Kooner J.S.; Koskinen S.; Kristiansson K.; Kutalik Z.; Laan M.; Larson M.; Launer L.J.; Lehne B.; Lehtimaki T.; Liewald D.C.M.; Lin L.; Lind L.; Lindgren C.M.; Liu Y.M.; Loos R.J.F.; Lopez L.M.; Lu Y.; Lyytikainen L.-P.; Mahajan A.; Mamasoula C.; Marrugat J.; Marten J.; Milaneschi Y.; Morgan A.; Morris A.P.; Morrison A.C.; Munson P.J.; Nalls M.A.; Nandakumar P.; Nelson C.P.; Niiranen T.; Nolte I.M.; Nutile T.; Oldehinkel A.J.; Oostra B.A.; O'Reilly P.F.; Org E.; Padmanabhan S.; Palmas W.; Palotie A.; Pattie A.; Penninx B.W.J.H.; Perola M.; Peters A.; Polasek O.; Pramstaller P.P.; Nguyen Q.T.; Raitakari O.T.; Ren M.; Rettig R.; Rice K.; Ridker P.M.; Ried J.S.; Riese H.; Ripatti S.; Robino A.; Rose L.M.; Rotter J.I.; Rudan I.; Ruggiero D.; Saba Y.; Sala C.F.; Salomaa V.; Samani N.J.; Sarin A.-P.; Schmidt R.; Schmidt H.; Shrine N.; Siscovick D.; Smith A.V.; Snieder H.; Sober S.; Sorice R.; Starr J.M.; Stott D.J.; Strachan D.P.; Strawbridge R.J.; Sundstrom J.; Swertz M.A.; Taylor K.D.; Teumer A.; Tobin M.D.; Tomaszewski M.; Toniolo D.; Traglia M.; Trompet S.; Tuomilehto J.; Tzourio C.; Uitterlinden A.G.; Vaez A.; van der Most P.J.; van Duijn C.M.; Vergnaud A.-C.; Verwoert G.C.; Vitart V.; Volker U.; Vollenweider P.; Vuckovic D.; Watkins H.; Wild S.H.; Willemsen G.; Wilson J.F.; Wright A.F.; Yao J.; Zemunik T.; Zhang W.; Attia J.R.; Butterworth A.S.; Chasman D.I.; Conen D.; Cucca F.; Danesh J.; Hayward C.; Howson J.M.M.; Laakso M.; Lakatta E.G.; Langenberg C.; Melander O.; Mook-Kanamori D.O.; Palmer C.N.A.; Risch L.; Scott R.A.; Scott R.J.; Sever P.; Spector T.D.; van der Harst P.; Wareham N.J.; Zeggini E.; Levy D.; Munroe P.B.; Newton-Cheh C.; Brown M.J.; Metspalu A.; Hung A.M.; O'Donnell C.J.; Edwards T.L.; Psaty B.M.; Tzoulaki I.; Barnes M.R.; Wain L.V.; Elliott P.; Caulfield M.J./titolo:Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits/doi:10.1038%2Fs41588-018-0205-x/rivista:Nature genetics (Online)/anno:2018/pagina_da:1412/pagina_a:1425/intervallo_pagine:1412–1425/volume:50, Nature Genetics, 50(10), 1412-1431. Nature Publishing Group, Nature Genetics, Vol. 50, No 10 (2018) pp. 1412-1425, Keavney, B, Tomaszewski, M, Morris, A & et al 2018, ' Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits ', Nature Genetics, vol. 50, no. 10, pp. 1412-1425 . https://doi.org/10.1038/s41588-018-0205-x, Boomsma, D I, de Geus, E J C, Hottenga, J J, Willemsen, G & the Million Veteran Program 2018, ' Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits ', Nature Genetics, vol. 50, no. 10, pp. 1412-1431 . https://doi.org/10.1038/s41588-018-0205-x, the Million Veteran Program 2018, ' Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits ', Nature Genetics, vol. 50, no. 10, pp. 1412-1425 . https://doi.org/10.1038/s41588-018-0205-x, Nature Genetics, Nature Publishing Group, 2018, 50 (10), pp.1412-1425. ⟨10.1038/s41588-018-0205-x⟩, Nature Genetics, 50(10), 1412, Nature Genetics, 50(10), 1412-1425. 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