Additional file 1 of Decreasing dorsal cochlear nucleus activity ameliorates noise-induced tinnitus perception in mice

Additional file 1 Fig. S1. Bimodal unit responses seen upon CNO administration in hM4Di+ mice. A) Left; Firing rate in response to 80dBSPL at best frequency for all units (n = 122) from hM4Di+ mice in response to NaCl or CNO. Middle; Only units decreasing (n = 96) firing rate upon CNO administration. Right; Units increasing (n = 26) firing rate after CNO administration. B) Same as ‘A’ but for Tuning width, with units decreasing (n = 71) and increasing (n = 51) tuning with after CNO administration. C) Same as ‘A’ for representation of Best frequency in kHz, with units decreasing (n = 30), increasing (n = 56) or maintaining (n = 36) Best frequency response upon CNO administration. Note that units responding to sound do not need to be CaMKII α+, the unit altered firing properties are in response to sound when CNO is decreasing activity of CaMKII α+ units of the DCN circuit. *: p