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The cardiomyopathy in Friedreich's ataxia — New biomarker for staging cardiac involvement
- Source :
- International Journal of Cardiology. 194:50-57
- Publication Year :
- 2015
- Publisher :
- Elsevier BV, 2015.
-
Abstract
- BackgroundPatients with autosomal-recessively inherited Friedreich's ataxia (FA) may develop a hypertrophic cardiomyopathy (CM), which potentially progresses towards a life-limiting problem. The typical features of this CM and the sequence of progression are widely unknown.MethodsThirty-two consecutive patients with genetically confirmed FA were included. All patients received resting electrocardiogram (ECG), 24-hour Holter-ECG, echocardiography with speckle tracking imaging, cardiac magnetic resonance imaging (cMRI) with late enhancement imaging (for replacement fibrosis), and measurement of high-sensitive troponin-T (hsTNT). In addition, morphological parameters were retrospectively compared to data obtained five years before.ResultsBased on criteria comprising ejection fraction (
- Subjects :
- Adult
Male
medicine.medical_specialty
Ataxia
Cardiomyopathy
Muscle hypertrophy
Electrocardiography
Troponin T
Fibrosis
Cardiac magnetic resonance imaging
Internal medicine
medicine
Humans
Retrospective Studies
Ejection fraction
medicine.diagnostic_test
business.industry
Hypertrophic cardiomyopathy
Friedreich's ataxia
Blood Pressure Monitoring, Ambulatory
Cardiomyopathy, Hypertrophic
Middle Aged
medicine.disease
Magnetic Resonance Imaging
Echocardiography
Friedreich Ataxia
Cardiology
Electrocardiography, Ambulatory
Biomarker (medicine)
Female
medicine.symptom
business
Cardiology and Cardiovascular Medicine
Biomarkers
Subjects
Details
- ISSN :
- 01675273
- Volume :
- 194
- Database :
- OpenAIRE
- Journal :
- International Journal of Cardiology
- Accession number :
- edsair.doi.dedup.....1c1969c27cdcf28837d75aa9a59eb90e
- Full Text :
- https://doi.org/10.1016/j.ijcard.2015.05.074