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Impact of Fasting Glycemia on Short-Term Prognosis after Acute Myocardial Infarction
- Source :
- The Journal of Clinical Endocrinology & Metabolism. 92:2136-2140
- Publication Year :
- 2007
- Publisher :
- The Endocrine Society, 2007.
-
Abstract
- The prognosis of patients with acute myocardial infarction (MI), according to the new criteria for impaired fasting glucose (IFG) (FG 100-126 mg/dl), has not been evaluated.A total of 2353 patients with acute MI and surviving at d 5 after admission were analyzed for short-term morbidity and mortality. FG was obtained at d 4 and 5. Patients were classified as diabetes mellitus (known diabetes or FGor = 126 mg/dl), high IFG (110or = FG126 mg/dl), low IFG (100or = FG110 mg/dl), and normal fasting glucose (NFG) (FG100 mg/dl).Among the 2353 patients, 968 (41%) had diabetes mellitus, 262 (11%) had high IFG, 332 (14%) had low IFG, and 791 (34%) had NFG. Compared with NFG patients, 30-d cardiovascular mortality was increased in high but not low IFG subjects. In-hospital heart failure was increased in high IFG subjects (42 vs. 20% for NFG, P0.0001) but not low IFG subjects (21 vs. 20%). High IFG, but not low IFG, was an independent factor associated with 30-d cardiovascular mortality [odds ratio 2.33 (1.55-3.47)] and in-hospital heart failure [odds ratio 1.70 (1.36-2.07)]. The optimal threshold levels of FG on the receiver-operating characteristic curves were 114 and 112 mg/dl to predict mortality and in-hospital heart failure, respectively.The present study, based on a nonselected cohort of MI patients, underscores the high prevalence of IFG (25%) and highlights the clinical relevance of 110 mg/dl, but not 100 mg/dl, as a cutoff value to define the risk for worse outcome.
- Subjects :
- Blood Glucose
Male
medicine.medical_specialty
endocrine system diseases
Heart disease
Endocrinology, Diabetes and Metabolism
Clinical Biochemistry
Myocardial Infarction
Sensitivity and Specificity
behavioral disciplines and activities
Biochemistry
Cohort Studies
Fasting glucose
Endocrinology
Risk Factors
Internal medicine
Diabetes mellitus
Diabetes Mellitus
Prevalence
medicine
Humans
Myocardial infarction
Acute mi
Aged
Cardiovascular mortality
business.industry
Biochemistry (medical)
nutritional and metabolic diseases
Fasting
Middle Aged
Prognosis
medicine.disease
Impaired fasting glucose
ROC Curve
Hyperglycemia
Heart failure
Female
Morbidity
business
hormones, hormone substitutes, and hormone antagonists
psychological phenomena and processes
Subjects
Details
- ISSN :
- 19457197 and 0021972X
- Volume :
- 92
- Database :
- OpenAIRE
- Journal :
- The Journal of Clinical Endocrinology & Metabolism
- Accession number :
- edsair.doi.dedup.....1c14c28efc340f95e0695a3478936a03
- Full Text :
- https://doi.org/10.1210/jc.2006-2584