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Pediatric Hemophagocytic Syndromes: A Diagnostic and Therapeutic Challenge

Authors :
Geneviève de Saint Basile
Christine McCusker
Nada Jabado
BMC, Ed.
Department of Paediatrics
McGill University = Université McGill [Montréal, Canada]-Montreal Children's Hospital
McGill University Health Center [Montreal] (MUHC)-McGill University Health Center [Montreal] (MUHC)
Division of Allergy and Immunology
Developpement Normal et Pathologique du Système Immunitaire
Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)
McGill University-Montreal Children's Hospital
McGill University Health Center [Montreal, Canada] ( MUHC ) -McGill University Health Center [Montreal, Canada] ( MUHC )
Université Paris Descartes - Paris 5 ( UPD5 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS )
Source :
Allergy, Asthma & Clinical Immunology, Vol 1, Iss 4, Pp 142-160 (2005), Allergy, Asthma and Clinical Immunology, Allergy, Asthma and Clinical Immunology, 2005, 1 (4), pp.142-60. ⟨10.1186/1710-1492-1-4-142⟩, Allergy, Asthma and Clinical Immunology, BioMed Central, 2005, 1 (4), pp.142-60. 〈10.1186/1710-1492-1-4-142〉, Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology, Allergy, Asthma and Clinical Immunology, BioMed Central, 2005, 1 (4), pp.142-60. ⟨10.1186/1710-1492-1-4-142⟩
Publication Year :
2005
Publisher :
BMC, 2005.

Abstract

Pediatric hemophagocytic syndrome (HS) is a severe and often fatal clinical disorder. This syndrome is frequently unrecognized, and thus, affected children may receive suboptimal management, leading to an increase in mortality. The purpose of this review is to provide a clinical guide to (1) the recognition of HS based on clinical, biologic, and pathologic features; (2) the identification of the primary cause of HS in a given affected child; and (3) the initiation of effective treatment in a timely manner.

Details

Language :
English
ISSN :
17101492 and 17101484
Volume :
1
Issue :
4
Database :
OpenAIRE
Journal :
Allergy, Asthma & Clinical Immunology
Accession number :
edsair.doi.dedup.....1c01b6fc5a718986b641d959801c1361