Back to Search
Start Over
Molecular mechanisms regulating myelination in the peripheral nervous system
- Source :
- Trends in neurosciences
- Publication Year :
- 2012
- Publisher :
- Elsevier BV, 2012.
-
Abstract
- Glial cells and neurons are engaged in a continuous and highly regulated bidirectional dialog. A remarkable example is the control of myelination. Oligodendrocytes in the central nervous system (CNS) and Schwann cells (SCs) in the peripheral nervous system (PNS) wrap their plasma membranes around axons to organize myelinated nerve fibers that allow rapid saltatory conduction. The functionality of this system is critical, as revealed by numerous neurological diseases that result from deregulation of the system, including multiple sclerosis and peripheral neuropathies. In this review we focus on PNS myelination and present a conceptual framework that integrates crucial signaling mechanisms with basic SC biology. We will highlight signaling hubs and overarching molecular mechanisms, including genetic, epigenetic, and post-translational controls, which together regulate the interplay between SCs and axons, extracellular signals, and the transcriptional network.
- Subjects :
- 0303 health sciences
Myelinated nerve fiber
General Neuroscience
Multiple sclerosis
Saltatory conduction
Central nervous system
Biology
medicine.disease
Axons
03 medical and health sciences
0302 clinical medicine
medicine.anatomical_structure
nervous system
Cell Movement
Peripheral nervous system
Peripheral Nervous System
medicine
Extracellular
Animals
Schwann Cells
Epigenetics
Neuroscience
Myelin Sheath
030217 neurology & neurosurgery
030304 developmental biology
Subjects
Details
- ISSN :
- 01662236
- Volume :
- 35
- Database :
- OpenAIRE
- Journal :
- Trends in Neurosciences
- Accession number :
- edsair.doi.dedup.....1bfab0c136e12a59210232df8eaef9e0