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Baseline use of hydroxychloroquine or immunosuppressive drugs and the risk of coronavirus disease 2019
- Source :
- The Korean Journal of Internal Medicine. 37:673-680
- Publication Year :
- 2022
- Publisher :
- Korean Association of Internal Medicine, 2022.
-
Abstract
- Background/Aims: The preventive role of hydroxychloroquine (HCQ) on coronavirus disease 2019 (COVID-19) remains unclear. The aim of this study was to examine the effects of HCQ and other immunosuppressive drugs on the incidence of COVID-19.Methods: The data were collected from the South Korea National Health Insurance Sharing-COVID-19 database. All individuals who underwent nasopharyngeal and oropharyngeal swab tests for COVID-19 from January 2020 to May 2020 are included. The association between COVID-19 risk and HCQ use was examined in a propensity score-matched population. Factors associated with COVID-19 were identified using multiple logistic regression analysis.Results: Total 8,070 patients with COVID-19 and 121,050 negative controls were included from the database. Among all participants, 381 were HCQ users. In a propensity score-matched population, the incidence of COVID-19 was 7.1% in HCQ users and 6.8% in non-users. The odds ratio (OR) for HCQ use was 1.05 with a 95% confidence interval (CI) of 0.58 to 1.89. Among the subpopulation of patients with rheumatoid arthritis (RA), 33 were diagnosed with COVID-19 and 478 were not. Use of HCQ, glucocorticoids, or other immunosuppressive drugs was not associated with COVID-19 risk, whereas abatacept use was. Chronic lung disease was an independent risk factor for COVID-19 diagnosis in patients with RA (adjusted OR, 6.07; 95% CI, 1.10 to 33.59).Conclusions: The risk of COVID-19 did not differ between HCQ users and non-users. Glucocorticoids, conventional disease-modifying antirheumatic drugs (DMARDs), and biological DMARDs other than abatacept did not increase the risk of COVID-19.
- Subjects :
- medicine.medical_specialty
Population
Abatacept
Arthritis, Rheumatoid
03 medical and health sciences
COVID-19 Testing
0302 clinical medicine
Internal medicine
medicine
Humans
Risk factor
education
Glucocorticoids
education.field_of_study
business.industry
Incidence (epidemiology)
COVID-19
Hydroxychloroquine
Odds ratio
medicine.disease
Confidence interval
COVID-19 Drug Treatment
Antirheumatic Agents
Rheumatoid arthritis
030211 gastroenterology & hepatology
business
Immunosuppressive Agents
medicine.drug
Subjects
Details
- ISSN :
- 20056648 and 12263303
- Volume :
- 37
- Database :
- OpenAIRE
- Journal :
- The Korean Journal of Internal Medicine
- Accession number :
- edsair.doi.dedup.....1bf4ee6f17600e13e94751062b89b823