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The parotid gland connection: ultrasound and biopsies in primary Sjögren’s syndrome
- Source :
- Annals of the Rheumatic Diseases, 77(7):e38. BMJ PUBLISHING GROUP
- Publication Year :
- 2017
- Publisher :
- BMJ, 2017.
-
Abstract
- We would like to thank Alegria et al 1 for their letter to the editor commenting on our recent publication entitled ‘Ultrasonography of major salivary glands compared with parotid and labial gland biopsy and classification criteria in patients with clinically suspected primary Sjogren’s syndrome’.2 Our study was the first that directly compared the validity of ultrasound of major salivary glands (sUS) with parotid gland biopsy outcome. We showed that the agreement between sUS and parotid as well as labial gland biopsies was good but was slightly higher for the former. As noted by Alegria et al ,1 we found different results for the positive predictive value (PPV) and negative predictive value (NPV) between sUS versus parotid and sUS versus labial gland biopsies.2 Although these observations may indeed be caused by discordance between the parotid and labial gland biopsy outcome, there are other factors that may equally well contribute to this discrepancy. First, the parotid glands are assessed during the sUS examination and included in the scoring, whereas the labial glands are not.2 Second, in 6%–15% of the general population, the labial gland biopsy is positive, while in only 5% of the general population, the parotid gland biopsy is positive. …
- Subjects :
- 0301 basic medicine
Pathology
medicine.medical_specialty
Letter to the editor
Immunology
Population
AMERICAN-COLLEGE
General Biochemistry, Genetics and Molecular Biology
03 medical and health sciences
0302 clinical medicine
stomatognathic system
Rheumatology
Major Salivary Gland
Biopsy
Labial glands
Immunology and Allergy
Medicine
CLASSIFICATION CRITERIA
DATA-DRIVEN
education
030203 arthritis & rheumatology
education.field_of_study
medicine.diagnostic_test
business.industry
Ultrasound
Parotid gland
stomatognathic diseases
030104 developmental biology
medicine.anatomical_structure
Ultrasonography
CONSENSUS
business
Subjects
Details
- ISSN :
- 14682060 and 00034967
- Volume :
- 77
- Database :
- OpenAIRE
- Journal :
- Annals of the Rheumatic Diseases
- Accession number :
- edsair.doi.dedup.....1bda4b6eb29a17a1586666f3ca9a2b5b
- Full Text :
- https://doi.org/10.1136/annrheumdis-2017-212331