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Lung pharmacokinetics of inhaled and systemic drugs: A clinical evaluation

Authors :
Jens M. Hohlfeld
Meike Müller
Cornelia Faulenbach
Philipp Badorrek
Olaf Holz
Markus Fridén
Birthe D. Ellinghusen
Stina Stomilovic
Ulf Eriksson
Anders Lundqvist
Muhammad Waqas Sadiq
Source :
British journal of pharmacologyREFERENCES. 178(22)
Publication Year :
2021

Abstract

Background and purpose Human pharmacokinetic studies of lung-targeted drugs are typically limited to measurements of systemic plasma concentrations, which provide no direct information on lung target-site concentrations. We aimed to evaluate lung pharmacokinetics of commonly prescribed drugs by sampling different lung compartments after inhalation and oral administration. Experimental approach Healthy volunteers received single, sequential doses of either inhaled salbutamol, salmeterol, and fluticasone propionate (n=12), or oral salbutamol and propranolol (n=6). Each participant underwent bronchoscopies and gave breath samples for analysis of particles in exhaled air at two time points after drug administration (1 and 6, 2 and 9, 3 and 12, or 4 and 18 hours). Lung samples were taken via bronchosorption, bronchial brush, mucosal biopsy, and bronchoalveolar lavage during each bronchoscopy. Blood samples were taken during the 24 hours after administration. Pharmacokinetic profiles were generated by combining data from multiple individuals, covering all sample timings. Key results Pharmacokinetic profiles were obtained for each drug in lung epithelial lining fluid, lung tissue, and plasma. Inhalation of salbutamol resulted in approximately 100-fold higher concentrations in lung versus plasma. Salmeterol and fluticasone concentration ratios in lung versus plasma were higher still. Bronchosorption- and bronchoalveolar-lavage-generated profiles of inhaled drugs in epithelial lining fluid were comparable, whereas, for oral drugs, epithelial-lining-fluid concentrations appeared to be overestimated in bronchoalveolar-lavage-generated profiles. Conclusion and implications Combining pharmacokinetic data derived from multiple individuals and techniques sampling different lung compartments enabled generation of pharmacokinetic profiles for evaluation of lung targeting after inhaled and oral drug delivery.

Details

ISSN :
14765381
Volume :
178
Issue :
22
Database :
OpenAIRE
Journal :
British journal of pharmacologyREFERENCES
Accession number :
edsair.doi.dedup.....1bc0802c18d1419cfb1bf19dcb9f3424